Sökning: "Microvesicles"

Visar resultat 21 - 25 av 33 avhandlingar innehållade ordet Microvesicles.

  1. 21. Translational studies of syndecan-1 as angiogenesis inhibitor : from basic research to clinical applications

    Författare :Joman Javadi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malignant mesothelioma (MM) is a highly aggressive primary tumor of the pleura, associated with poor prognosis. MM is mainly related to exposure to mineral fibers such as asbestos. The diagnosis of MM, despite multiple diagnostic tools, is challenging and treatment options are limited. LÄS MER

  3. 22. Exosomes and the NKG2D receptor-ligand system in pregnancy and cancer : using stress for survival

    Författare :Malin Hedlund; Lucia Mincheva-Nilsson; Susanne Gabrielsson; Umeå universitet; []
    Nyckelord :Exsosomes; NKG2D; MICA; MICB; ULBP; human placenta; trophoblast; syncytiotrophoblast; thermal stress; oxidative stress; leukemia; lymphoma; immunologi; Immunology;

    Sammanfattning : Although not obvious at first sight, several parallels can be drawn between pregnancy andcancer. Many proliferative, invasive and immune tolerance mechanisms that supportnormal pregnancy are also exploited by malignancies to establish a nutrient supply andevade or edit the immune response of the host. LÄS MER

  4. 23. Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and Astrocytes

    Författare :Sofia Söllvander; Lars Lannfelt; Anna Erlandsson; Frida Ekholm-Pettersson; Linda Söderberg; Pär Gellerfors; Martin Hallbeck; Uppsala universitet; []
    Nyckelord :Alzheimer s Disease; Amyloid-beta; Protofibrils; ELISA; ELISpot; Astrocyte; Monoclonal Antibody; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Soluble amyloid-beta (Aβ) aggregates, including Aβ protofibrils, play a central role in Alzheimer’s disease (AD) and constitute a potential diagnostic biomarker and a therapeutic target. Aβ protofibrils promote synapse dysfunction and neurodegeneration, but the mechanisms behind these effects remain unclear. LÄS MER

  5. 24. Metastatic Mechanisms in Malignant Tumors

    Författare :Linda Bojmar; Per Sandström; Olle Stål; Marie Larsson; Ingemar Ernberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The ultimate cause of cancer related deaths is metastasis. This thesis is about three of the main human cancers; breast, colorectal and pancreatic cancer, that together account for more than 25% of the cancer-related deaths worldwide. LÄS MER

  7. 25. Extracellular vesicles : mediators of immune modulation in the lung and as therapeutic vehicles

    Författare :Casper Ullsten-Wahlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Extracellular vesicles (EVs) are released from all cell types, and carry a wide setup of proteins, nucleic acids, lipids and other cargo. The overall aim of this thesis is to explore EV-based immune therapy, but also to find clues on mechanisms of the inflammatory disease sarcoidosis, and of lung cancer. LÄS MER