Sökning: "MHC-I gene expression"

Hittade 5 avhandlingar innehållade orden MHC-I gene expression.

  1. 1. Avian MHC : Characterization and expression patterns of classical and non-classical MHC-I genes

    Författare :Anna Drews; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MCH class I; Classical genes; Non-classical genes; Expression; Passerine birds;

    Sammanfattning : The function of the vertebrate immune system is to enable recognition and elimination of microorganisms that can cause harm (pathogens). A key component in adaptive immunity is the major histocompatibility complex (MHC) that codes for molecules with antigen presentation function. LÄS MER

  3. 2. MHC diversity and expression in a songbird : Temporal and transgenerational variation

    Författare :Samantha Mellinger; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MHC diversity; MHC-I gene expression; songbirds; genome assembly; amplicon HTS; temporal variation; family data; great reed warbler Acrocephalus arundinaceus ;

    Sammanfattning : The immune system is of central importance to clear-off pathogens in order to keep an organism healthy. In vertebrates, the Major Histocompatibility Complex (MHC) is a genomic region that holds key genes involved in adaptive immunity and in particular in the antigen presenting process. LÄS MER

  4. 3. Immune and gene therapies for cancer and infectious diseases

    Författare :Jehad Charo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Immunotherapy; gene therapy; cytokines; MHC-1; tucaresol; EBV; mycobacteria; HER-2; Tumors;

    Sammanfattning : Annually more than 20 million deaths are globally caused because of infections or cancer. This accounts for 41.5% of annual deaths. New techniques are supposed to constitute our tools in the fight against these types of deaths. LÄS MER

  5. 4. NK cells and missing self recognition : genetic control, mhc class i dependent education and potential use in cancer therapy

    Författare :Stina L Wickström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : NK cells belong to the innate immune system and are important in the defense against virus infections and malignant cells. They mediate their effector functions via release of cytotoxic granules and by cytokine production which can influence the status of other (immune) cells. LÄS MER

  7. 5. MHC and Transgenic Mice. A study into polymorphism and function of class I and class II molecules

    Författare :Mikael Vestberg; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MHC rat mouse transgenic autoimmunity collagen peptide; Clinical biology; Klinisk biologi;

    Sammanfattning : Transplantation antigens encoded in the major histocompatibility complex (MHC) bind peptides and present them to T cells. We showed that mouse T cells expressing transgenic human CD8 can recognise human MHC class I. LÄS MER