Sökning: "dog leukocyte antigen"

Hittade 3 avhandlingar innehållade orden dog leukocyte antigen.

1. 1. Genetic Studies of Immunological Diseases in Dogs and Humans

   Författare :Matteo Bianchi; Gerli Rosengren Pielberg; Marta Alarcón-Riquelme; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complex disease; immunogenetics; autoimmunity; GWAS; NGS; canine model; dog; hypothyroidism; Addison s disease; IFNA; BACH2; Medical Genetics; Medicinsk genetik;

   Sammanfattning : This thesis presents genetic studies aiming at enlarging our knowledge regarding the genetic factors underlying two immune-mediated diseases, hypothyroidism and autoimmune Addison’s disease (AAD), in dogs and humans, respectively.Genetic and environmental factors are indicated to contribute to canine hypothyroidism, which can be considered a model for human Hashimoto’s thyroiditis (HT). LÄS MER

3. 2. Evolution of MHC Genes and MHC Gene Expression

   Författare :Karin Berggren Bremdal; Hans Ellegren; Jennifer Seddon; Philip Hedrick; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; major histocompatibilty complex; dog leukocyte antigen; balancing selection; linkage disequilibrium; promoter; diabetes mellitus; Canis familiaris; Canis lupus; Erinaceus europaeus; Erinaceus concolor; Genetics; Genetik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Sammanfattning : Polymorphism in coding regions and regions controlling gene expression is the major determinant of adaptive differences in natural populations. Genes of the major histocompatibility complex (MHC) possess a high level of genetic variation, which is maintained by selection over long coalescence times. LÄS MER

4. 3. Discovery of a novel pathway for an SLE-related disease complex in the canine breed Nova Scotia duck tolling retriever

   Författare :Maria Wilbe; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The dog is an excellent model to study inherited complex diseases, due to its unique population history and haplotype structure. In this thesis, dogs from the breed Nova Scotia duck tolling retriever (NSDTR) have been used as a model for defining the genetic factors controlling a systemic lupus erythematosus (SLE)-related disorder called immune-mediated rheumatic disease (IMRD) and a steroid responsive meningitis-arteritis (SRMA). LÄS MER