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Visar resultat 16 - 20 av 64 avhandlingar som matchar ovanstående sökkriterier.

1. 16. Vascular actions of antimicrobial peptides

   Författare :Cristina Ciornei; Sektion II; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; vascular smooth muscle; sepsis; nitric oxide; human antimicrobial peptide LL-37; Antimicrobial peptides; lipopolysaccharide; bactericidal permeability-increasing protein;

   Sammanfattning : The present thesis focuses on the vascular effects of antimicrobial peptides especially mechanisms involving the vasodilator nitric oxide (NO), which is released from the blood vessel wall during inflammatory conditions such as sepsis. Bacterial lipopolysaccharide stimulates the expression of nitric oxide synthase (iNOS), which increases the NO production in vascular tissues or cultured vascular smooth muscle cells (VSMC). LÄS MER

3. 17. Antimicrobial peptides and proteins in innate immunity : emphasis on isolation, characterization and gene regulation

   Författare :Maria Tollin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Colon; vernix caseosa; rCRAMP; LL-37; cathelicidins; promoter studies;

   Sammanfattning : Antimicrobial peptides are endogenous antibiotics and effector molecules of Innate immunity. These peptides are mainly localised to epithelial linings and circulating neutrophils. They kill microbes by disruption of their membranes. The two main families of mammalian antimicrobial peptides are defensins and cathelicidins. LÄS MER

4. 18. Expression of cathelicidin antimicrobial peptides in man and rat

   Författare :Stefan Termén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :LL-37; rCRAMP; butyrate; colonic epithelium; central nervous system; transcription;

   Sammanfattning : Endogenous antimicrobial peptides are effectors of innate immunity. They kill microorganisms by disrupting their cell membranes, but are also believed to have signaling functions in the immune system. They are present in epithelia, secretions and phagocytic cells. LÄS MER

5. 19. The human antimicrobial protein hCAP18/LL37 in wound healing and cell proliferation

   Författare :Johan Heilborn; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Innate immunity; antimicrobial peptides; LL-37; epithelial cell; keratinocytes; proliferation; reepithelialization; wound healing; tissue repair; angiogenesis; tumor growth; vitamin D;

   Sammanfattning : Epithelia constitute the principal barriers separating the host and the potentially injurious environment, and defence of this interface is therefore essential. Antimicrobial peptides are key effector molecules of the innate immune system. LÄS MER

7. 20. The human antimicrobial peptide hCAP18 in epithelial defense

   Författare :Margareta Frohm Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Innate immunity; host defense; antimicrobial peptide; hCAP 18; LL-37; epithelia; wounds; breast cancer;

   Sammanfattning : Gene-encoded antimicrobial peptides serve a protective role in host defense. They are multifunctional effector molecules in innate immunity - the nonadaptive immune system -with the capacity to kill a broad spectrum of microorganisms. LÄS MER