Sökning: "Institutionen för immunteknologi"

Visar resultat 11 - 15 av 77 avhandlingar innehållade orden Institutionen för immunteknologi.

1. 11. Tailoring of Antibody Arrays - Technical Advances Towards Global Proteome Analysis

   Författare :Linn Petersson; Institutionen för immunteknologi; []
   Nyckelord :antibody arrays; recombinant antibodies; scFv; miniaturization of arrays; immobilization of scFv; global proteome analysis; biomarker discovery;

   Sammanfattning : Abstract The number of cancer and autoimmune disease diagnoses increases in our society, which place high demands on the health care system. Being able to tailor treatments for each individual patient is called "Personalized medicine", and could revolutionize the care in the future. LÄS MER

3. 12. Advances and Applications of Antibody Arrays - Proteomic Profiling of Pancreatic Disease

   Författare :Anna Sandström Gerdtsson; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; affinity proteomics; antibody microarray; pancreatic cancer; pancreatitis; biomarker; immunosignature;

   Sammanfattning : Recombinant antibody microarrays have advanced into indispensable tools for large-scale, high-throughput multiplexed serum proteomics. This thesis, based upon five original papers, deals with the development of an in-house designed antibody microarray platform, and its applications for serum profiling of pancreatic disease. LÄS MER

4. 13. Biomarker Discovery in Cancer using Affinity Proteomics - Studies of B-cell lymphomas and Breast Cancer

   Författare :Frida Pauly; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; affinity proteomics; antibody microarray; cancer; B-cell lymphoma; breast cancer; biomarker discovery;

   Sammanfattning : The continual increase in incidence of cancer has created an urgent need for improved methods for diagnosis, prognosis and/or treatment. In this context, the field of biomarker research has expanded immensely during the last few years. This thesis, based on four original papers, revolves around protein biomarker discovery in cancer. LÄS MER

5. 14. A Proteomic Dissection of Breast Cancer - Via Cells and Organelles to Pathways

   Författare :Linn Antberg; Institutionen för immunteknologi; []
   Nyckelord :Proteomics; Mass spectrometry; Breast cancer; DNA repair; Organelle fractionation; Tumour subpopulations;

   Sammanfattning : Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide. Breast tumours are extremely heterogeneous, and each patient’s disease has different causes, prognosis and appropriate treatments associated with it. LÄS MER

7. 15. Human IgE - What We Can Learn from Repertoire Studies and How We Can Use Them as Tools

   Författare :Mattias Levin; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allergy; antibodies; IgE; transcriptome analysis; immunotherapy; molecular biology;

   Sammanfattning : Antibodies of the IgE isotype play a key role as the allergen recognizer in allergic disease, which today affects as much as a third of the population in the industrialized parts of the world. Despite this crucial role of IgE, our knowledge of IgE repertoires and how we can utilize the information hidden in monoclonal IgE to improve the quality of life of allergic patients, is limited. LÄS MER