Sökning: "B-cell lymphoma"

Visar resultat 1 - 5 av 116 avhandlingar innehållade orden B-cell lymphoma.

  1. 1. Protein kinases and phosphatases in B-cell lymphoma

    Detta är en avhandling från Inst för Laboratoriemedicin, Avd för tumörbiologi, Malmö Universitetssjukhus, Lunds Universitet

    Författare :Marie Fridberg; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HePTP; PTEN; PKC-beta 2; B-cell; lymphoma; kinases; ZAP70; phosphatase; SHP2;

    Sammanfattning : Around 2000 persons are diagnosed with lymphoma in Sweden each year. There are many subgroups described for this form of cancer and the great majority is derived from B-cells. The most common subgroup is Diffuse large B-cell lymphoma (DLBCL), a highly aggressive disease where only half of the patients are cured. LÄS MER

  2. 2. Aggressive B-cell Lymphomas Studies of Treatment, FDG-PET Evaluation and Prognostic Factors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Magdalena Adde; Gunilla Enblad; Hans Hagberg; Anna Laurell; Tor Ekman; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Oncology; Onkologi;

    Sammanfattning : To improve outcome in young, high-risk lymphoma patients, treatment was intensified, adding etoposide and rituximab to standard CHOP treatment. Granulocyte-colony stimulating factor (G-CSF) enabled treatment bi-weekly. Results were promising: overall (OS) and event-free survival (EFS) 79% and 60% respectively, median follow up 27 months. LÄS MER

  3. 3. Immunoglobulin Gene Analysis in Different B cell Lymphomas With Focus on Cellular Origin and Antigen Selection

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mia Thorsélius; Richard Rosenquist Brandell; Christer Sundström; Anders Rosén; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma; Immunoglobulin; V gene; somatic hypermutation; antigen selection; quantitative PCR; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik;

    Sammanfattning : B cell lymphoma (BCL) comprises a biologically and clinically heterogeneous group of tumors deriving from different stages of B cell development. The immunoglobulin (Ig) variable heavy chain (VH) gene rearrangement is unique for each BCL and can be used to reveal cellular origin, to study signs of antigen selection and to quantify tumor cell load. LÄS MER

  4. 4. Molecular Characterization of Diffuse Large B-cell Lymphoma and Aspects of Transformation

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mattias Berglund; Uppsala universitet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Diffuse large B-cell lymphoma; Hodgkin lymphoma; follicular lymphoma; transformation; comparative genomic hybridization; prognosis; Onkologi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi;

    Sammanfattning : Lymphomas are a heterogeneous group of neoplasias originating from B- or T-lymphocytes. In this thesis, we determined the genetic and immunophenotypic characterization of DLBCL and their prognostic impact. LÄS MER

  5. 5. Analysis of Immunoglobulin Genes and Telomeres in B cell Lymphomas and Leukemias

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sarah Walsh; Richard Rosenquist; Christer Sundström; Anna Laurell; Andreas Rosenwald; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma leukemia; mantle cell lymphoma; hairy cell leukemia; lymphoplasmacytic lymphoma; immunoglobulin genes; antigen selection; telomeres; cellular origin; somatic hypermutation; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik;

    Sammanfattning : B cell lymphomas and leukemias are heterogeneous tumors with different cellular origins. Analysis of immunoglobulin (Ig) genes enables insight into the B cell progenitor, as Ig somatic hypermutation correlates with antigen-related B cell transit through the germinal center (GC). LÄS MER