Sökning: "Tumour subpopulations"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Tumour subpopulations.

  1. 1. A Proteomic Dissection of Breast Cancer - Via Cells and Organelles to Pathways

    Författare :Linn Antberg; Institutionen för immunteknologi; []
    Nyckelord :Proteomics; Mass spectrometry; Breast cancer; DNA repair; Organelle fractionation; Tumour subpopulations;

    Sammanfattning : Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide. Breast tumours are extremely heterogeneous, and each patient’s disease has different causes, prognosis and appropriate treatments associated with it. LÄS MER

  3. 2. Anti-idiotypic immunity in multiple myeloma and monoclonal gammopathy of undetermined significance

    Författare :Susanne Bergenbrant Glas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Monoclonal gammopathies such as multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are lymphoproliferative B cell diseases. B cells/plasma cells produce the monoclonal immunoglobulin (Ig) which can be detected in plasma and/or urine. LÄS MER

  4. 3. Clinical proteomics : quantitative analysis and biological interpretation

    Författare :AnnSofi Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main expectations of applying proteomics technologies to clinical questions are the discovery of disease related biomarkers. Despite technological advancement to increase proteome coverage and depth to meet these expectations the number of generated biomarkers for clinical use is small. LÄS MER

  5. 4. Analysis of extracellular vesicles and their application in immunotherapy

    Författare :Rosanne E Veerman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Extracellular Vesicles (EVs) are nano-sized particles secreted by most, if not all, cell types. They are important mediators in intercellular communication and carry a broad array of biomolecules such as lipids, nucleic acids and proteins. LÄS MER

  7. 5. Magnetic bead-based isolation of biological therapeutic modalities

    Författare :Nils A. Brechmann; Véronique Chotteau; Nigel Titchener-Hooker; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Magnetic bead separation; Magnetic beads; Protein A; Protein G; Negative cell isolation; Monoclonal antibody; induced pluripotent stem cells; human mesenchymal stem cells; Allogenic cell therapy; Biomanufacturing; cell clarification; Biotechnology; Bioteknologi;

    Sammanfattning : Biopharmaceutical modalities, such as monoclonal antibodies or the less established cell therapies, are nowadays very important for the treatment of severe or incurable diseases. The manufacturing of such modalities is complex and costly, including the downstream processing, which is highly essential to ensure the safety and quality of the product. LÄS MER