Sökning: "IL-1[beta]"

Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet IL-1[beta].

  1. 6. Inflammation in brain contusion

    Författare :Staffan Holmin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system is essential for host defense against microbial pathogens and for wound healing processes. Inflammatory reactions, however, invariably cause tissue damage. LÄS MER

  3. 7. Genetic control of myasthenia gravis : a study on cytokine and co-stimulator genes and their related functions

    Författare :DeRen Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Myasthenia gravis (MG) is a classical autoimmune disease characterised by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AchR) on the postsynaptic membrane of the neuromuscular junction. The aim of the study was to identify the role of the genes encoding potential immune components, such as TNF, IL-1, IL-1 receptor antagonist, IL-4, IL-10, and cytotoxic T lymphocyte antigen 4 (CTLA-4) in the pathogenesis of MG. LÄS MER

  4. 8. Cytokines, alcohol metabolizing enzymes and stress-inducible ER proteins in alcoholic liver disease

    Författare :Che Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The release of inflammatory cytokines by Kupffer cells is believed to be a key step in the pathogenesis of alcoholic liver disease (ALD). Kupffer cells are activated not only by endotoxins [lipopolysaccharides (LPS)] but also by the lipid peroxidation products generated mainly via ethanol-inducible cytochrome P450 2E1 (CYP2E1) redox cycling. LÄS MER

  5. 9. CXCL16 and CD137 in atherosclerosis

    Författare :Dick Wågsäter; Allan Sirsjö; Ewa Ehrenborg; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; atherosclerosis; chemokine; cytokine; endothelial cells; inflammation; low-density lipoprotein; macrophages; scavenger receptor; smooth muscle cells; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Sammanfattning : Atherosclerosis is a progressive inflammatory disease that is characterized by the accumulation of lipids, infiltrated cells and fibrous elements in large arteries. This thesis focuses on the molecular mechanisms behind foam cell formation and inflammation, two central processes in the development of atherosclerosis. LÄS MER

  7. 10. Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide

    Författare :Johanna S Ungerstedt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Sepsis; endotoxin; tissue factor; cytokines; nicotinamide; coagulation; inflammation;

    Sammanfattning : In gram negative sepsis, endotoxin from the bacterial membrane elicits proinflammatory and procoagulant host responses. Sepsis and its frequent complication disseminated intravascular coagulation (DIC) are leading causes of morbidity and mortality in the intensive care. LÄS MER