Sökning: "Hypoxia"

Visar resultat 26 - 30 av 443 avhandlingar innehållade ordet Hypoxia.

1. 26. Stromal and tumor cell responses to hypoxia and treatment within the glioma microenvironment

   Författare :Vasiliki Pantazopoulou; Avdelningen för translationell cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; glioblastoma; tumor microenvironment; reactive astrocytes; hypoxia; CD44; p75NTR;

   Sammanfattning : Glioblastoma is the most aggressive primary brain tumor in adults. Despite treatment, tumors invariably recur, and the recurring tumor is resistant to therapies. New approaches are needed for the successful treatment of glioblastoma patients.Tumors are not simply a compilation of molecularly and phenotypically identical neoplastic cells. LÄS MER

3. 27. The EEG of the Newborn Brain - Detection of Hypoxia and Prediction of Outcome

   Författare :Nils Löfgren; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; telemedicine; neonatal; prediction; infraslow EEG; cerebral; entropy; asphyxia; EEG; VLFA; hypoxia; Kolmogorov complexity; qEEG; detection; spectral estimation; newborn;

   Sammanfattning : Brain function requires a continuous flow of oxygen and an insufficient supply (hypoxia) for a few minutes during the first period of life may have severe consequences; consequences which might impact both the life of the individual who has been struck and his or her family. Therefore, there is a need to find a method which can enable the detection of an insufficient oxygen supply at an early stage, before brain damage becomes permanent. LÄS MER

4. 28. Influence of hypoxia on differentiation and proliferation of non-malignant and tumor cells

   Författare :Marica Vaapil; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypoxia; breast cancer; EPOR; small cell lung carcinoma; differentiation; proliferation; metabolism;

   Sammanfattning : Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. LÄS MER

5. 29. Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma

   Författare :Matilda Thorén; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small cell lung carcinoma; arsenic trioxide; hypoxia; hypoxia-inducible factors; survival; proliferation; glycolysis; glutamine metabolism; MYC;

   Sammanfattning : Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC tumors to relapse. LÄS MER

7. 30. Time, dose and fractionation: accounting for hypoxia in the search for optimal radiotherapy treatment parameters

   Författare :Emely Kjellsson Lindblom; Iuliana Toma-Dasu; Peter Wersäll; David J Carlson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hypoxia; radiobiological modelling; radiotherapy; functional imaging; Medical Radiation Physics; medicinsk strålningsfysik;

   Sammanfattning : The search for the optimal choice of treatment time, dose and fractionation regimen is one of the major challenges in radiation therapy. Several aspects of the radiation response of tumours and normal tissues give different indications of how the parameters defining a fractionation schedule should be altered relative to each other which often results in contradictory conclusions. LÄS MER