Sökning: "EPOR"

Hittade 4 avhandlingar innehållade ordet EPOR.

  1. 1. Influence of hypoxia on differentiation and proliferation of non-malignant and tumor cells

    Författare :Marica Vaapil; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypoxia; breast cancer; EPOR; small cell lung carcinoma; differentiation; proliferation; metabolism;

    Sammanfattning : Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. LÄS MER

  3. 2. Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer

    Författare :Anna-Maria Larsson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Anemia; Hypoxia; Erythropoietin EPO ; EPO receptor EPOR ; Estrogen Receptor ER ; Hypoxia-Inducible Factors HIFs ; Tamoxifen Response; Proliferation;

    Sammanfattning : The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different intracellular signaling pathways. LÄS MER

  4. 3. Erythropoietin receptor in growth control and anti-estrogen resistance of estrogen receptor positive breast cancer

    Författare :Susann Reinbothe; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tamoxifen resistance; proliferation; PI3k pathway; Breast cancer; erythropoietin receptor; estrogen receptor;

    Sammanfattning : The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Therefore, recombinant human EPO (rhEPO) is used to treat anemia in cancer patients, but some studies have reported that rhEPO treatment might promote tumor progression. Additionally, EPOR expression has been detected in various cancer forms. LÄS MER

  5. 4. To be or not to be, unraveling molecular mechanisms for lineage decisions in developing blood cells

    Författare :Robert Månsson; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; common lymphoid precursor CLP ; early B-cell factor 1 EBF1 ; B-cell; Stemcell; hematopoiesis; extracellulära vätskor; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : All hematopoietic cells originate from hematopoietic stem cells (HSC) residing in the BM. The process of differentiation, through which HSCs generate progenitors and subsequently mature blood cells has been extensively studied but many of the regulatory mechanisms involved remains elusive. LÄS MER