Sökning: "Hypoxia-inducible factors"

Visar resultat 16 - 20 av 45 avhandlingar innehållade orden Hypoxia-inducible factors.

1. 16. On VEGF and related factors in neurotrauma

   Författare :Mattias Sköld; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Spinal cord; brain; motoneuron; VEGF; VEGFR1; VEGFR2; Np1; Np2; Sema3A; HIF1alpha;

   Sammanfattning : At present, there is no cure for traumatic spinal cord and brain injuries. Therapies in use have only modest effect on outcome. Therefore, the need to better understand the biology of traumatic CNS injuries, making development of new therapies possible, is huge. LÄS MER

3. 17. Analysis of HIF-1alpha degradation and function

   Författare :Helder André; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hypoxia-inducible factor-1alpha; protein degradation; prolyl hydroxylases; adenoassociated virus; gene therapy; angiogenesis.;

   Sammanfattning : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. LÄS MER

4. 18. Regulators of angiogenesis in diabetes and tumors

   Författare :Sergiu-Bogdan Catrina; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Diabetes; HIF; hypoxia; tumors; growth factors; wound healing;

   Sammanfattning : Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular energy level and the potential risk of cellular oxidative damage. LÄS MER

5. 19. Prostate cancer and neuroendocrine differentiation. Molecular aspects in prostate cancer development

   Författare :Nastaran Monsef; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; neuron specific enolase; neuroendocrine differentiation; serotonin; hypoxia; cancer stem cell; synaptophysin; Gleason score; chromogranin A; Gleason grade;

   Sammanfattning : Hormone refractory prostate cancer occurs when androgen-deprivation therapy (ADT) fails to stop the growth of prostate cancer for any longer. Recent studies point towards a role for neuroendocrine (NE) differentiation in the development of hormone refractory disease. LÄS MER

7. 20. Hypoxia, PDGF and VEGF in Vascular Development

   Författare :Ingrid Nilsson; Lena Claesson-Welsh; Randall Johnson; Uppsala universitet; []
   Nyckelord :Cell biology; hypoxia; VEGF; VEGFR-3; PDGF; endothelial cell; embryonic stem cell; angiogenesis; lymphangiogenesis; Cellbiologi;

   Sammanfattning : The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not been elucidated in detail. The primary objectives of this thesis have therefore been to study the effects of hypoxia, platelet-derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs) on vascular development and function. LÄS MER