Sökning: "VEGFR-3"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet VEGFR-3.

  1. 1. Endothelial differentiation and angiogenesis regulation

    Författare :Johan Dixelius; Björn Olsen; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Angiogenesis; VEGFR-3; Laminin; endostatin; FGF-2; b-catenin; Genetik; Clinical genetics; Klinisk genetik; Molecular Medicine; molekylär medicin genetik och patologi ;

    Sammanfattning : Angiogenesis can be defined as the formation of new blood vessels from pre-existing ones. Angiogenesis is required for development and maintenance of our vascular system and thus of fundamental importance to our existence. LÄS MER

  2. 2. Hypoxia, PDGF and VEGF in Vascular Development

    Författare :Ingrid Nilsson; Lena Claesson-Welsh; Randall Johnson; Uppsala universitet; []
    Nyckelord :Cell biology; hypoxia; VEGF; VEGFR-3; PDGF; endothelial cell; embryonic stem cell; angiogenesis; lymphangiogenesis; Cellbiologi;

    Sammanfattning : The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not been elucidated in detail. The primary objectives of this thesis have therefore been to study the effects of hypoxia, platelet-derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs) on vascular development and function. LÄS MER

  3. 3. Functional genomics of vascular endothelial cells

    Författare :Elisabet Wallgard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Vasculature; endothelial cells; angiogenesis; vascular endothelial growth factor VEGF ; Notch; transcriptome; genomics; microarray; tumor; retina; morpholino knockdown;

    Sammanfattning : Angiogenesis, the formation of new blood vessels from preexisting ones, is a process involved in normal development as well as in several pathological conditions, such as cancer, ischemic heart disease, wound healing and certain retinal complications. Antiangiogenic targeting is therefore a promising new therapeutic principle. LÄS MER

  4. 4. The Role of VEGF family in angiogenesis, tumor growth and metastasis

    Författare :Xiaojuan Yang; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : Tumor growth is dependent on angiogenesis, and cells in tumor tissues produce various angiogenic factors to induce neovascularization. Among tumor-derived angiogenic factors, members of the vascular endothelial growth factor (VEGF) family are most frequently and highly expressed in various solid tumors. LÄS MER

  5. 5. Invasive and Metastatic Properties of Advanced Prostate Cancer

    Författare :Karin Jennbacken; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Prostate cancer; Androgen-independent; Castration-resistant; Metastasis; Invasion; Lymphangiogenesis; Cell adhesion; N-cadherin; VEGF-C; MRI;

    Sammanfattning : Prostate cancer is initially androgen-dependent (AD) and therefore androgen deprivation therapy (ADT) is generally used to treat advanced prostate cancer. However, the long-term treatment effects are insufficient and over time an androgen-independent (AI) tumor relapses, which is generally highly aggressive and metastatic. LÄS MER