Sökning: "Hypoxia-inducible factor-1alpha"

Hittade 2 avhandlingar innehållade orden Hypoxia-inducible factor-1alpha.

  1. 1. Hypoxia inducible factor 1a : Molecular mechanisms of regulation

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Författare :William J. Wilson; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Hypoxia-Inducible Factor 1alpha (HIF-1alpha) is an important protein in the homeostatic control of genes in response to low oxygen, or hypoxia. It is thus also a key factor in the regulation of angiogenesis in response to hypoxia, including induction of vascular endothelial growth factor (VEGF) gene expression. LÄS MER

  2. 2. Analysis of HIF-1alpha degradation and function

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Författare :Helder André; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypoxia-inducible factor-1alpha; protein degradation; prolyl hydroxylases; adenoassociated virus; gene therapy; angiogenesis.;

    Sammanfattning : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. LÄS MER