Sökning: "Hypospadias"

Visar resultat 11 - 15 av 20 avhandlingar innehållade ordet Hypospadias.

  1. 11. Etiological insights into the testicular cancer epidemic

    Författare :Olof Akre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Testicular neoplasms; seminoma; nonseminoma; epidemiology; etiology; risk factors; prenatal; fertility; birth weight; placenta; neonatal jaundice; cryptorchidism; hypospadias; preterm birth; Epstein-Barr virus; cytomegalovirus; Body Mass Index; height;

    Sammanfattning : The aim of this thesis was to search for causes of the testicular cancer epidemic through epidemiologic studies of testicular cancer and possibly related conditions, such as urogenital birth defects and subfertility. First, we assessed changes in fertility over time by studying time-to-pregnancy among primiparous women in Sweden from 1983 through 1993 using data from the Medical Birth Registry. LÄS MER

  3. 12. Psychological aspects in differences / disorders of sex development

    Författare :Anna Strandqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Sex differentiation depends on a complex set of molecular events. These are at one point initiated by SRY gene expression and involve gene transcription, which in turn can be affected by the prescence or absence of different co-factors, availability of and exposure to sex hormones, presence and sensitivity of steroid receptors that directs growth and development. LÄS MER

  4. 13. Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies

    Författare :Yasir Ruhayel; Malmö Molekylärgenetisk reproduktionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytoplasmic and nuclear; Receptors; Prostatic neoplasms; genetic; Polymorphism; male; Infertility; Hypogonadism; Genetic association studies; Case–control studies; Androgens;

    Sammanfattning : Androgen action plays a pivotal role in male reproductive tract physiology and pathology. The androgen receptor (AR) gene harbors two codon repeat tracts: the CAG and GGN repeats, encoding corresponding amino acid sequences of variable length; the polyglutamine and polyglycine stretches, respectively. LÄS MER

  5. 14. THE ANDROGEN RECEPTOR GGN POLYMORPHISM. Genetic and functional analyses

    Författare :Kristina Lundin; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Functional domain; Genetic predisposition; Reproductive function; Sex hormone; Transactivation function; Repeat; Polymorphism; Androgen receptor; Transcription factor; Medicin människa och djur ; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Male sex development and reproductive function is regulated by androgens acting via the androgen receptor (AR). The AR harbours two polymorphic repeats of CAG and GGN triplets, encoding glutamines and glycines, respectively. LÄS MER

  7. 15. The impact of genetic, environmental and life-style factors on male reproductive function

    Författare :Jonas Richthoff; Malmö Reproduktionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; male reproductive function; testicular cancer; smoking; Medicin människa och djur ; Medicine human and vertebrates ; cryptorchidism; sperm concentration;

    Sammanfattning : Recent studies have indicated a decline in sperm number in the western world during the past 50 years, sperm concentration changing from 113 to 66 millions per mL. Furthermore, significant geographical differences in male reproductive function have been observed. LÄS MER