Sökning: "Hypospadias"

Visar resultat 6 - 10 av 20 avhandlingar innehållade ordet Hypospadias.

  1. 6. Hypospadias : gene mapping and candidate gene studied

    Författare :Thi Thai Hanh Trinh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hypospadias is a common congenital malformation in boys, characterized by incomplete fusion of the urethral folds, abnormal opening of urethra and different degrees of curvature of the penis. In Sweden, the incidence of hypospadias is 1.14 per 300 male live-births according to the annual Swedish Malformation Registry. LÄS MER

  3. 7. Hypospadias : analysis of a complex genetic disorder

    Författare :Ana Maria Beleza Meireles; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : BACKGROUND: Hypospadias is a common inborn error of the male urethra that involves an abnormally placed urethral opening. Its complex etiology is largely elusive to date. Twin and familial studies highlight a genetic background in hypospadias. Environmental factors have also been identified, particularly the exposure to endocrine disrupters. LÄS MER

  4. 8. Lifelong health and well-being in men born with hypospadias

    Författare :Lottie Phillips; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hypospadias is a congenital malformation defined by an ectopic placement of the urethral orifice along the ventral side of the penis, with a large variation in phenotype from distal to proximal. There are both genetic and environmental risk factors, often related to an impact on androgen function which is central in the development of male genitalia. LÄS MER

  5. 9. Molecular Characterisation of Structural Chromosomal Abnormalities Associated with Congenital Disorders

    Författare :Mahmoud R. Mansouri; Niklas Dahl; Hans Van Bokhoven; Uppsala universitet; []
    Nyckelord :Genetics; Chromosomal abnormalities; Mental retardation; Hypospadias and anal malformation; Premature ovarian failure; Autism; Array-CGH; ZDHHC15; Genetik;

    Sammanfattning : Chromosomal abnormalities are defined as changes in the chromosome structure and fall in one of two categories. The first category is numerical alterations while the second category consists of structural abnormalities. Structural chromosomal abnormalities do not always interrupt genes in order to cause disease. LÄS MER

  7. 10. Urothelial cell culturing : in vitro and in vivo studies in reconstructive pediatric surgery

    Författare :Magdalena Fossum; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hypospadias; Tissue Engineering; Urethra; Clinical Trials; Autologous Transplantation; Cell Culture; Urothelium; Fibroblasts; Smooth Muscle Cells; 3T3 Cells;

    Sammanfattning : In Pediatric Surgery many malformations present underdevelopment of tissues and organs. When surgical treatment is needed, the reconstruction can sometimes be restricted because of shortage of tissue for the repair. LÄS MER