Sökning: "Genetic association studies"

Visar resultat 1 - 5 av 519 avhandlingar innehållade orden Genetic association studies.

  1. 1. Genetic Determinants of Dyslipidemia

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Tibor V Varga; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic epidemiology; Genetic polymorphism; dyslipidaemia; Cholesterol; Triglyceride; Genetic risk; genetic risk score; Single nucleotide polymorphism; Prediction; Gene-environment interactions; Randomized controlled trial; prospective cohort studies; Observational study; GLACIER Study; Diabetes Prevention Program;

    Sammanfattning : Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (LDL-C) have a strong genetic underpinning, not much is known about the genetic factors that affect long-term deteriorations in lipid concentrations. LÄS MER

  2. 2. Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Yasir Ruhayel; Lunds universitet.; Lund University.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytoplasmic and nuclear; Receptors; Prostatic neoplasms; genetic; Polymorphism; male; Infertility; Hypogonadism; Genetic association studies; Case–control studies; Androgens;

    Sammanfattning : Popular Abstract in Swedish De manliga könshormonerna, sk. androgener, spelar en nyckelroll under foster-utvecklingen av de manliga inre (t ex. blåshalskörtel/prostata) och yttre (t ex. penis) könsorganen. LÄS MER

  3. 3. Genetic variation and prostate cancer population-based association studies in Sweden

    Detta är en avhandling från Umeå : Strålningsvetenskaper

    Författare :Sara Lindström; Umeå universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; epidemiology; SRD5A2; ERG; progression; genetics; association studies; polymorphism; haplotype; CDH1; AR; CYP17; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi;

    Sammanfattning : Prostate cancer constitutes the most common malignancy and the most common cause of cancer‐related death in Swedish men. A large body of evidence suggests that inherited genetic variants contribute to both development and progression of prostate cancer. LÄS MER

  4. 4. Genetic studies of diabetes in northern Sweden

    Detta är en avhandling från Umeå : Medicinsk biovetenskap

    Författare :Sofia Mayans; Umeå universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; families; genetic; association; SNP; linkage; TCF7L2; CTLA-4; Calpain-10; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Medical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Medicinsk genetik;

    Sammanfattning : Diabetes mellitus represents a group of metabolic disorders caused by both environmental and genetic factors. The two most common forms of diabetes are type 2 diabetes (T2D) and type 1 diabetes (T1D). T2D is associated with obesity and the disease is caused by insulin resistance and pancreatic b-cell dysfunction. LÄS MER

  5. 5. Genetic aspects of stroke association and linkage studies in a northern Swedish population

    Detta är en avhandling från Umeå : Folkhälsa och klinisk medicin

    Författare :Per-Gunnar Wiklund; Umeå universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Internal medicine; stroke; genetics; polymorphism; association; linkage; risk factors; plasminogen activator inhibitor-1; tissue plasminogen activator; angiotensin converting enzyme; angiotensin II receptor type 1; phosphodiesterase 4D; Invärtesmedicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin; medicin; Medicine;

    Sammanfattning : Stroke is a common, multifactorial cardiovascular disease. A stroke event is the result of traditional risk factors (i.e. hypertension, diabetes, smoking), environmental exposures and genetic factors in a complex interplay. LÄS MER