Sökning: "Gram-negative"
Visar resultat 21 - 25 av 279 avhandlingar innehållade ordet Gram-negative.
21. Immunity to Salmonella infection
Sammanfattning : The immune system has several strategies to combat infections. The present study investigates various aspects of the interaction between Gram negative bacteria, particularly Salmonella, and antigen presenting cells (APC). Salmonella is an intracellular bacterium infecting mice and man. LÄS MER
22. Design and synthesis of KDO-derivatives as inhibitors of lipopolysaccharide biosynthesis in Gram-negative bacteria : a new class of antibacterial agents
Sammanfattning : .... LÄS MER
23. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development
Sammanfattning : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. LÄS MER
24. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance
Sammanfattning : Exposure to antibiotics is an important factor influencing the development of bacterial resistance. In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. LÄS MER
25. Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
Sammanfattning : Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal vaccines. LÄS MER