Sökning: "vaccine development"

Visar resultat 1 - 5 av 226 avhandlingar innehållade orden vaccine development.

  1. 1. Characterizing important flavivirus-host interactions : Replication, assembly, restriction factors and vaccine development

    Författare :Pham Tue Hung Tran; Magnus Johansson; Wessam Melik; Naveed Asghar; Sören Andersson; Laurent Chatel-Chaix; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Flaviviruses; virus-host cell interaction; lunapark; ESCRT; ALIX; CHMP4A; ISG15; TRIMs; replicon virus-like particles; vaccine;

    Sammanfattning : The genus Flavivirus (family Flaviviridae) consists of important zoonotic viruses that cause morbidity and mortality worldwide. These viruses are enveloped and have a positive-sense single-stranded RNA genome encoding a polyprotein. LÄS MER

  3. 2. Development of a Cancer Vaccine Targeting Tumor Blood Vessels

    Författare :Elisabeth J. M Huijbers; Anna-Karin Olsson; Arjan W. Griffioen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vaccine; Therapeutic; Cancer; Tumor; Angiogenesis; Immunization; Vascular; Extracellular matrix; Biomedicinsk laboratorievetenskap; Biomedical Laboratory Science; Medical Cell Biology; Medicinsk cellbiologi; Oncology; Onkologi; Medical Science; Medicinsk vetenskap;

    Sammanfattning : A treatment strategy for cancer is the suppression of tumor growth by directing an immune response to the tumor vessels, which will destroy the tissue.In this thesis we describe the development of a vaccine that targets antigens expressed around angiogenic vasculature in most solid tumors. LÄS MER

  4. 3. Heat shock proteins as vaccine adjuvants

    Författare :Khaleda Rahman Qazi; Carmen Fernández; Qijun Chen; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heat shock protein; vaccine; adjuvant; BCG; Immunology; Immunologi;

    Sammanfattning : New efficient vaccines against infectious diseases are in demand. Some important factors impeding the vaccine development are the poor immunogenicity and the MHC restriction of the immune responses to a number of antigens. LÄS MER

  5. 4. The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development

    Författare :Farshid Jalalvand; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABC-transporter; bacterial colonization; Haemophilus influenzae; Haemophilus Protein F; laminin; NTHi; pathogenesis; vaccine; virulence; vitronectin.;

    Sammanfattning : Nontypeable Haemophilus influenzae (NTHi) is a remarkably proficient colonizer of the human respiratory tract. The aim of this thesis has been to characterize currently known, and identify novel, bacterial factors involved in the key processes of colonization and pathogenesis, namely adherence to host tissue and evasion of the host innate immunity. LÄS MER

  7. 5. Development of a vaccine against strangles

    Författare :Margareta Flock; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Strangles is an acute upper respiratory tract disease in the horse, which is characterized by purulent pharyngitis and lymphadenitis. It is caused by Streptococcus equi subsp. equi. The severe suffering and economical losses due to Streptococcus equi infections makes it one of the most important bacterial diseases in horses. LÄS MER