Sökning: "GTPase"
Visar resultat 6 - 10 av 94 avhandlingar innehållade ordet GTPase.
6. Signal Transduction in Malignant Cells – Transformation, Activation and Differentiation
Sammanfattning : All aspects of cell life are regulated by signal transduction mechanisms. This thesis describes the regulatory roles of a few key signal transduction molecules involved in three major biological responses. LÄS MER
7. Anaplastic Lymphoma Kinase mutations and downstream signalling
Sammanfattning : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. LÄS MER
8. From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster
Sammanfattning : Embryonic development is associated with extensive rearrangements of tissues. The driving force for these rearrangements is generated by a dynamic reorganization of the Actin cytoskeleton of individual cells. LÄS MER
9. Rho-GTPases in Morphogenesis and Differentiation of the Developing Pancreas
Sammanfattning : Branched tubular networks constitute the basic structure of many organs to increase surface area and to transport fluids and gases. Glandular organs such as the pancreas arise from multilayered epithelium, which undergoes de novo lumen formation and extensive remodeling and branching. LÄS MER
10. The atypical Rho GTPase RhoD and its role in cellular dynamics
Sammanfattning : Despite its discovery 20 years ago, the accumulated knowledge about the Rho member RhoD is scarce. Instead, the vast majority of studies concerning Rho GTPases has focused on the three classical members RhoA, Cdc42 and Rac1. In contrast, RhoD is considered an atypical Rho GTPase, with an aberrant GTP/GDP cycling and an unknown regulation. LÄS MER
