Sökning: "Hedgehog"

Visar resultat 1 - 5 av 50 avhandlingar innehållade ordet Hedgehog.

  1. 1. Repressing the hedgehog signalling pathway

    Författare :Jessica Svärd; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation of the pathway is found in tumours. Mutations in Hh pathway components are found in several tumour types, including basal cell carcinoma (BCC) and medulloblastoma (MB). LÄS MER

  3. 2. The role of polysaccharide modifications during Drosophila development

    Författare :Florian Lüders; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ontogeni; growth animal ; embryologi; Development biology; Decapentaplegic; Hedgehog; Wingless; Sulfation; Pipe; Glycosaminoglycan; Glycosyltransferase; ontogeny; embryology; Utvecklingsbiologi;

    Sammanfattning : Glucosides attached to proteins and lipids have been shown to modulate the activity of signal transduction pathways regulating growth and patterning processes during animal development. In particular, O-linked glycans such as glycosaminoglycans (GAGs) have been implicated in modulation of growth factor signaling pathways. LÄS MER

  4. 3. From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster

    Författare :Shai Mulinari; Sociologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Odd-skipped; morphogenesis; Hedgehog; segment boundaries; segmental grooves; Actin; Drosophila; DRhoGEF2; Myosin; Diaphanous; Rho GTPase; cytoskeleton; Rho1;

    Sammanfattning : Embryonic development is associated with extensive rearrangements of tissues. The driving force for these rearrangements is generated by a dynamic reorganization of the Actin cytoskeleton of individual cells. LÄS MER

  5. 4. Mechanisms of hedgehog signaling activation in cancer development

    Författare :Mohammed Ferdous-Ur Rahman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hedgehog (HH) signaling has an important role in many physiological processes, and deregulation of this pathway can result in a wide range of malignancies. The aim of this thesis is to identify and evaluate the role of various posttranscriptional mechanisms, including alternative splicing, RNA editing and antisense RNAs, associated with different key components of HH signaling. LÄS MER

  7. 5. Regulation of Hedgehog signalling during development and carcinogenesis

    Författare :Marie Fiaschi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hedgehog (Hh) signalling is one of the most important signalling networks in the body and, when miss-regulated, has been implicated in many human tumours, particularly that of skin (Basal Cell Carcinoma, BCC) and brain (medulloblastoma). BCC most commonly arises due to mutations in the gene sequence of the Hh receptor protein PATCHED1 (PTCH1). LÄS MER