Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet tubulogenesis.
Sammanfattning : The kidney and the renin-angiotensin system (RAS) are vital regulators of blood pressure and salt-water balance. In order to appropriately regulate circulatory homeostasis, the kidney must undergo normal development, in which the RAS plays a crucial role. LÄS MER
Sammanfattning : The formation of an epithelial organ requires a set of organ-specific gene programs that instruct parallel and successive developmental events. Still, it is unclear what are the core regulatory programs and how such programs are timely coordinated within the organ. LÄS MER
Sammanfattning : Branched tubular networks constitute the basic structure of many organs to increase surface area and to transport fluids and gases. Glandular organs such as the pancreas arise from multilayered epithelium, which undergoes de novo lumen formation and extensive remodeling and branching. LÄS MER
Sammanfattning : Diabetes affects enormous amounts of patients. In type 1 diabetes the insulin producing β cells in the islet of Langerhans are destroyed by the immune system. The β cells, which are located in the pancreas, regulate blood glucose levels. The lack of insulin production requires administration of insulin. LÄS MER
Sammanfattning : The formation of branched tubular organs, such as the mammalian lung kidney and vascular system, is an essential process in animal development. The Drosophila tracheal (respiratory) system provides a genetic model system to study the highly ordered process of branch outgrowth and fusion required to form continuous tubular networks. LÄS MER