Sökning: "GPCR"
Visar resultat 31 - 35 av 84 avhandlingar innehållade ordet GPCR.
31. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties
Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER
32. Intestinal Gene Expression Profiling and Fatty Acid Responses to a High-fat Diet
Sammanfattning : The gastrointestinal tract (GIT) regulates nutrient uptake, secretes hormones and has a crucial gut flora and enteric nervous system. Of relevance for these functions are the G protein-coupled receptors (GPCRs) and the solute carriers (SLCs). LÄS MER
33. The Dark side of Obesity: Multi-omics analysis of the dysmetabolic morbidities spectrum
Sammanfattning : Obesity is one of the most prevalent clinical conditions worldwide and is associated with a wide spectrum of dysmetabolic comorbidities. Complex cardio-metabolic disease cohorts, such as obesity cohorts are characterised by population heterogeneity, multiple underlying diseases status and different comorbidities’ treatment regiments. LÄS MER
34. The impact of GPCR structures on understanding receptor function and ligand binding
Sammanfattning : G protein-coupled receptors (GPCRs) form the largest superfamily of eukaryotic membrane proteins and are responsible for the action of nearly 30% of all marketed drugs. For a long period, efforts to study these receptors were limited by the paucity of atomic-resolution structural information. LÄS MER
35. Old receptors learn new tricks : biasing anti-IGF1R cancer therapy through the GPCR system
Sammanfattning : As cancers progress, tumor cells exploit the extracellular signals generated from plasma membrane receptors for cell growth, migration, and anti-apoptosis. G protein-coupled receptors (GPCR) and receptor tyrosine kinases (RTKs) are two important families of plasm membrane receptors, controlling multiple biological functions via their downstream signaling. LÄS MER