Sökning: "multi-omics integration"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden multi-omics integration.
1. Image-based multi-omics data integration : Exploring whole-body PET/MRI, -omics data and body composition
Sammanfattning : Advanced body composition analysis with whole-body imaging could uncover novel associations between regional tissue composition and metabolic disease. Imiomics is an automated image analysis framework that enables large-scale integration of magnetic resonance imaging (MRI) data and orthogonal technologies such as metabolomics and genomics for the detailed study of body composition. LÄS MER
2. On metabolic networks and multi-omics integration
Sammanfattning : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. LÄS MER
3. The Dark side of Obesity: Multi-omics analysis of the dysmetabolic morbidities spectrum
Sammanfattning : Obesity is one of the most prevalent clinical conditions worldwide and is associated with a wide spectrum of dysmetabolic comorbidities. Complex cardio-metabolic disease cohorts, such as obesity cohorts are characterised by population heterogeneity, multiple underlying diseases status and different comorbidities’ treatment regiments. LÄS MER
4. In search of early biomarkers in pancreatic ductal adenocarcinoma using multi-omics and bioinformatics
Sammanfattning : Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy with a 5-year survival of 10 %. Surgery is the only curative treatment. Unfortunately, few patients are eligible for surgery due to late detection. Thus, we need ways to detect the disease at an earlier stage and for that good screening biomarkers could be used. LÄS MER
5. Interplay between inflammation and calcification in cardiovascular diseases
Sammanfattning : Cardiovascular calcification has been linked to all-cause mortality and is a broadly adopted predictor of cardiovascular (CV) events. Rather than a mere by-product of the changing disease environment, calcification impacts actively the disease progression and pathogenesis as it predominates both in early- and late-stages, through mediating tissue biomechanical destabilisation and directly impacting tissue inflammation. LÄS MER