Sökning: "Adhesion GPCR"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Adhesion GPCR.

  1. 1. Characterization and Evolution of Transmembrane Proteins with Focus on G-protein coupled receptors in Pre-vertebrate Species

    Författare :Karl J. V. Nordström; Helgi B. Schiöth; Robert Fredriksson; Teresa Attwood; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptors; GPCR; Membrane protein; Rhodopsin; Adhesion; Secretin; Evolution; Bioinformatics; Phylogeny; Pharmacological research; Farmakologisk forskning; Bioinformatics; Bioinformatik; Bioinformatik; Bioinformatics; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

    Sammanfattning : G protein-coupled receptors (GPCRs) are one of the largest protein families in mammals. GPCRs are instrumental for hormonal and neurotransmitter signalling and are important in all major physiological systems of the body. LÄS MER

  3. 2. Identification, Characterization and Evolution of Membrane-bound Proteins

    Författare :Pär J. Höglund; Helgi B. Schiöth; Robert Fredriksson; Gert Vriend; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; G protein-coupled receptor; GPCR; Solute Carriers; SLC; Bioinformatics; Evolution; Rhodopsin; Adhesion; Phylogeny; Pharmacology; Farmakologi;

    Sammanfattning : Membrane proteins constitute approximately 30% of all genes in the human genome and two large families of membrane proteins are G protein-coupled receptors (GPCRs) and Solute Carriers (SLCs) with about 800 and 380 human genes, respectively.In Papers I, II and IV, we report 16 novel human Adhesion GPCRs found by searches in NCBI and Celera databases. LÄS MER

  4. 3. G Protein-Coupled Receptors; Discovery of New Human Members and Analyses of the Entire Repertoires in Human, Mouse and Rat

    Författare :David E. Gloriam; Helgi Schiöth; Robert Fredriksson; Darren Flower; Uppsala universitet; []
    Nyckelord :Bioinformatics; G protein-coupled receptor; GPCR; Bioinformatics; Evolution; Orphan; Rhodopsin; Adhesion; Phylogeny; Bioinformatik;

    Sammanfattning : G protein-coupled receptors (GPCRs) are signal mediators that have a prominent role in the regulation of physiological processes and they make up the targets for 30-45% of all drugs. Papers I and II describe the discovery of new human GPCRs belonging to the Rhodopsin family, a family which contains many common drug targets. LÄS MER

  5. 4. The Gene Repertoire of G protein-coupled Receptors : New Genes, Phylogeny, and Evolution

    Författare :Þóra Kristín Bjarnadóttir; Helgi B. Schiöth; Robert Fredriksson; Kurt Kristiansen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Bioinformatics; Evolution; GPCR; Phylogeny; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Sammanfattning : The superfamily of G protein-coupled receptors (GPCRs) is one of the largest protein families of mammalian genomes and can be divided into five main families; Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin. GPCRs participate in most major physiological functions, contributing to the fact that they are important targets in drug discovery. LÄS MER

  7. 5. Intestinal Gene Expression Profiling and Fatty Acid Responses to a High-fat Diet

    Författare :Jonathan Cedernaes; Helgi B Schiöth; Robert Fredriksson; Anders Jacobsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adhesion GPCR; delta-5 desaturase; delta-6 desaturase; desaturase index; Diet-induced obesity; estimated desaturase activity; fatty acid composition; gas chromatography; gastrointestinal tract; G-protein coupled receptor; high-fat diet; intestine; linoleic acid; liver; mRNA expression; palmitoleic acid; plasma; phospholipids; proximodistal; RT-qPCR; solute carrier; SCD-1; SCD-16; SCD-18; stearoyl-CoA desaturase; subcutaneous adipose tissue; subsection; triacylglycerols.; Medical Genetics; Medicinsk genetik; Nutrition; Nutrition; Näringslära; Nutrition;

    Sammanfattning : The gastrointestinal tract (GIT) regulates nutrient uptake, secretes hormones and has a crucial gut flora and enteric nervous system. Of relevance for these functions are the G protein-coupled receptors (GPCRs) and the solute carriers (SLCs). LÄS MER