Sökning: "GPCR"
Visar resultat 21 - 25 av 84 avhandlingar innehållade ordet GPCR.
21. The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion
Sammanfattning : Type 2 diabetes (T2D) is a serious condition of growing proportions. Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose concentration, e.g. after a meal. LÄS MER
22. G Protein-Coupled Receptors; Discovery of New Human Members and Analyses of the Entire Repertoires in Human, Mouse and Rat
Sammanfattning : G protein-coupled receptors (GPCRs) are signal mediators that have a prominent role in the regulation of physiological processes and they make up the targets for 30-45% of all drugs. Papers I and II describe the discovery of new human GPCRs belonging to the Rhodopsin family, a family which contains many common drug targets. LÄS MER
23. Calcium and Phospholipases in Orexin Receptor Signaling
Sammanfattning : The neuropeptides orexin-A and -B act as endogenous ligands for G-protein-coupled receptors (GPCRs) called OX1 and OX2 receptors. Previous observations have established that orexin receptors have an ability to couple to different G-proteins and signaling pathways and induce Ca2+ elevations via both receptor-operated Ca2+ channels (ROCs) and store-operated Ca2+ channels (SOCs). LÄS MER
24. Regulation and Function of the Human Leukotriene D4 Receptor CysLT1 in Epithelial Cells and Colon Cancer
Sammanfattning : The pro-inflammatory mediators leukotrienes have shown to be important players in the pathogenesis of diseases like asthma and inflammatory bowel disease (IBD). Patients suffering from IBD have been found to have an increased risk of developing colon cancer. LÄS MER
25. Development of sensitive cellular assay systems and their application to the identification of "orphan" seven-transmembrane receptors
Sammanfattning : Seven-transmembrane, G-protein coupled receptors play a central role in physiology since they facilitate cell communication in multicellular organisms by recognition of a broad range of ligands. They also represent important drug targets. LÄS MER