Sökning: "Exosome."

Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet Exosome..

  1. 1. Novel roles of ErbB3 receptor tyrosine kinase in vesicular trafficking

    Författare :Ana Rosa Saez-Ibañez; Ingvar Ferby; Carl-Henrik Heldin; Johanna Ivaska; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ErbB3; Integrin; GGA3; Rabaptin5; PKD; Ack1; endocytic recycling; exosome; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : ErbB3 is a catalytically impaired receptor tyrosine kinase (RTK) from the EGFR family. Upon ligand binding, ErbB3 forms heterodimers with other members of the family and triggers phosphorylation cascades that promote crucial cellular functions as proliferation, differentiation and survival. LÄS MER

  3. 2. Towards specific quantification of exosomes using surface-based sensing

    Författare :Deborah Rupert; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; label-free; surface plasmon resonance.; exosome; binding rate; antibody; concentration; nanoparticle tracking analysis; quantification; liposome; cluster of differentiation 63 CD63 ; diffusion; specific detection; mass transport limited conditions; extracellular vesicles; surface-based biosensor;

    Sammanfattning : When exosomes were first observed in 1967, they were believed to be cell debris until extensive studies demonstrated key biological functionalities related to their composition and formation mechanism. Exosomes are nanometer-sized lipid vesicles of endocytic origin, with a membrane consisting of lipids and proteins and encapsulating a cargo composed of soluble proteins and genetic material. LÄS MER

  4. 3. Mediator and its role in non-coding RNA and chromatin regualtion

    Författare :Jonas O P Carlsten; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mediator; transcription; centromere; telomere; tRNA; exosome;

    Sammanfattning : Mediator is a multiprotein complex required for the regulation of RNA Polymerase II (Pol II) transcription. Mediator transmits regulatory signals from activators and repressors to the Pol II machinery at the promoter, but the complex has also many other functions related to control of gene transcription. LÄS MER

  5. 4. mRNA degradation factors as regulators of the gene expression in Saccharomyces cerevisiae

    Författare :Mridula Muppavarapu; Tracy Nissan; Per Sunnerhagen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mRNA decapping; mRNA degradation; Pat1; Edc3; Lsm4; Lsm1-7; P bodies; Dcp2; Transcription; Ribosome biogenesis; Exosome.; molekylärbiologi; Molecular Biology;

    Sammanfattning : Messenger RNA degradation is crucial for the regulation of eukaryotic gene expression. It not only modulates the basal mRNA levels but also functions as a quality control system, thereby controlling the availability of mRNA for protein synthesis. LÄS MER

  7. 5. Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment

    Författare :Helena Christianson; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microvesicle; exosome; Key words Extracellular vesicle; glioblastoma; hypoxia; angiogenesis; acidosis; proteoglycan; endocytosis; carbonic anhydrase IX; biomarker.;

    Sammanfattning : The transition from normal into malignant cells with acquired uncontrolled growth is a process where cancer cells viciously develop adaptive strategies to overcome microenvironmental and metabolic stress. Hypoxia, or deficient oxygen supply, is a common feature of the expanding tumor which alters cell metabolism and consecutively causes lowered intracellular pH. LÄS MER