Sökning: "mRNA degradation"

Visar resultat 1 - 5 av 137 avhandlingar innehållade orden mRNA degradation.

  1. 1. mRNA degradation factors as regulators of the gene expression in Saccharomyces cerevisiae

    Författare :Mridula Muppavarapu; Tracy Nissan; Per Sunnerhagen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mRNA decapping; mRNA degradation; Pat1; Edc3; Lsm4; Lsm1-7; P bodies; Dcp2; Transcription; Ribosome biogenesis; Exosome.; molekylärbiologi; Molecular Biology;

    Sammanfattning : Messenger RNA degradation is crucial for the regulation of eukaryotic gene expression. It not only modulates the basal mRNA levels but also functions as a quality control system, thereby controlling the availability of mRNA for protein synthesis. LÄS MER

  3. 2. Allosteric Regulation of mRNA Metabolism : -Mechanisms of Cap-Dependent Regulation of Poly(A)-specific Ribonuclease (PARN)

    Författare :Per Nilsson; Anders Virtanen; Megerditch Kiledjian; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; mRNA degradation; deadenylation; cap; poly A ; PARN; allosteric regulation; Cell- och molekylärbiologi;

    Sammanfattning : Degradation of mRNA is a highly regulated step important for proper gene expression. Degradation of eukaryotic mRNA is initiated by shortening of the 3’ end located poly(A) tail. Poly(A)-specific ribonuclease (PARN) is an oligomeric enzyme that degrades the poly(A) tail with high processivity. LÄS MER

  4. 3. Spatial control of mRNA stability in yeast

    Författare :Susanne Huch; Tracy Nissan; Anders Byström; Anders Virtanen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mRNA stability; P bodies; mRNA turnover; gene regulation; decapping factors; molekylärbiologi; Molecular Biology;

    Sammanfattning : The degradation of mRNA is an important modulator of gene expression and the ultimate fate of messenger mRNA. Important steps in the degradation of mRNA include initial shortening of its poly(A) tail followed by the subsequent removal of the m7G cap. These two processes are linked temporally as well as spatially. LÄS MER

  5. 4. Studies on mRNA turnover in bacteria

    Författare :Martin Persson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; aprE; GlpP; glpD; mRNA secondary structure; Bacillus subtilis; mRNA stability; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Genetic information, which is stored in DNA, is transferred to messenger RNA (mRNA) in a process called transcription. mRNAs are then translated by ribosomes into proteins which, with some important exceptions, catalyze chemical reactions in cells. Since cells must be able to adapt to changes in the environment, mRNAs must be unstable. LÄS MER

  7. 5. Regulation of pre-mRNA splicing and mRNA degradation in Saccharomyces cerevisiae

    Författare :Yang Zhou; Marcus Johansson; Anders Byström; Marie Öhman; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMD; RES complex; pre-mRNA splicing; magnesium homeostasis;

    Sammanfattning : Messenger RNAs are transcribed and co-transcriptionally processed in the nucleus, and transported to the cytoplasm. In the cytoplasm, mRNAs serve as the template for protein synthesis and are eventually degraded. The removal of intron sequences from a precursor mRNA is termed splicing and is carried out by the dynamic spliceosome. LÄS MER