Sökning: "microvesicle"

Hittade 5 avhandlingar innehållade ordet microvesicle.

  1. 1. Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment

    Författare :Helena Christianson; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microvesicle; exosome; Key words Extracellular vesicle; glioblastoma; hypoxia; angiogenesis; acidosis; proteoglycan; endocytosis; carbonic anhydrase IX; biomarker.;

    Sammanfattning : The transition from normal into malignant cells with acquired uncontrolled growth is a process where cancer cells viciously develop adaptive strategies to overcome microenvironmental and metabolic stress. Hypoxia, or deficient oxygen supply, is a common feature of the expanding tumor which alters cell metabolism and consecutively causes lowered intracellular pH. LÄS MER

  3. 2. Microvesicle signaling in cardiovascular biology under normal and pathobiological conditions

    Författare :Paulina Bryl-Gorecka; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microvesicles; cardiovascular disease; atherosclerosis; biomarkers; acoustic trapping;

    Sammanfattning : Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Atherosclerosis, a chronic pathology directly related to the circulatory system, develops due to an interplay between several molecular events. Atherosclerotic plaque build-up can lead to a reduction in arterial blood flow and finally, myocardial infarction (MI). LÄS MER

  4. 3. Mechanisms of Shiga toxin-mediated signaling and toxicity

    Författare :Karl Johansson; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EHEC; Shiga toxin; Microvesicles; Purinergic Receptors;

    Sammanfattning : AbstractShiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli (EHEC). EHEC strains cause gastrointestinal infection and release Stx that can gain access to the circulation. Patients may develop hemolytic uremic syndrome with extensive kidney damage. LÄS MER

  5. 4. Gastrointestinal stromal tumours. On diagnosis and treatment

    Författare :Per Bümming; Göteborgs universitet; []
    Nyckelord :adjuvant; epidemiology; GIST; imatinib; KIT; mutation; neoadjuvant; neuroendocrine phenotype; PET; prognosis; surgery; vesicle proteins;

    Sammanfattning : Gastrointestinal stromal tumours (GIST) are thought to originate from the interstitial cells of Cajal, which show many properties in common with neurons of the gastrointestinal tract. High-risk GIST has a very poor prognosis and tumour recurrence is common after intentionally curative surgery. LÄS MER

  7. 5. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling

    Författare :Urban Hellman; Anders Waldenström; Stellan Mörner; Anna Engström-Laurent; Lena Jonasson; Umeå universitet; []
    Nyckelord :hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. LÄS MER