Sökning: "Ack1"

Hittade 2 avhandlingar innehållade ordet Ack1.

1. 1. Novel Roles of the Ack1 Kinase in Epithelial Biology

   Författare :Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. LÄS MER

3. 2. Novel roles of ErbB3 receptor tyrosine kinase in vesicular trafficking

   Författare :Ana Rosa Saez-Ibañez; Ingvar Ferby; Carl-Henrik Heldin; Johanna Ivaska; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ErbB3; Integrin; GGA3; Rabaptin5; PKD; Ack1; endocytic recycling; exosome; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : ErbB3 is a catalytically impaired receptor tyrosine kinase (RTK) from the EGFR family. Upon ligand binding, ErbB3 forms heterodimers with other members of the family and triggers phosphorylation cascades that promote crucial cellular functions as proliferation, differentiation and survival. LÄS MER