Sökning: "Epigenetics"

Visar resultat 36 - 40 av 111 avhandlingar innehållade ordet Epigenetics.

  1. 36. Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases

    Författare :Juliana Imgenberg-Kreuz; Gunnel Nordmark; Ann-Christine Syvänen; Johanna K Sandling; Amr Sawalha; Uppsala universitet; []
    Nyckelord :Autoimmunity; DNA methylation; Primary Sjögren’s syndrome; Systemic lupus erythematosus; Gene expression; Type I interferon system; Epigenetics; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Autoimmune diseases are clinical manifestations of a loss-of-tolerance of the immune system against the body’s own substances and healthy tissues. Primary Sjögren’s syndrome (pSS) and systemic lupus erythematosus (SLE) are two chronic inflammatory autoimmune diseases characterized by autoantibody production and an activated type I interferon system. LÄS MER

  3. 37. Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials

    Författare :Henrik Jespersen; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; Uveal melanoma; Humanized mouse models; Immunotherapy; Chimeric antigen receptor T cells; PD-1 inhibition; Epigenetics; Histone deacetylase inhibition;

    Sammanfattning : Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the treatment has little or no effect. LÄS MER

  4. 38. The Impact of Our Lifestyle on the Epigenome and Metabolism

    Författare :Josefine Jönsson; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epigenetik; Livsstil; Kost; Fysisk aktivitet; WGBS; DNA metylering; Fetma; Graviditet; Avkomma; Sperma; Humana pankreas öar; Navelsträngsblod; Muskel massa; Tillväxt; Födelsevikt; Genexpression; Fertilitet; Human hälsa; Typ 2 diabetes; Epigenetics; Lifestyle; Physical activity; Diet; WGBS; DNA methylation; Obesity; Pregnancy; Offspring; Sperm; Human islets; Cord blood; Lean mass; Growth; Birthweight; Gene expression; Fertility; Human health; Type 2 Diabetes;

    Sammanfattning : .... LÄS MER

  5. 39. Chromatin, histones, and epigenetic tags

    Författare :Elisavet Koutzamani; Ingemar Rundquist; Herbert Lindner; Sergey Belikov; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromatin; histones; histone variants; epigenetics; histone H4 methylation; linker histone phosphorylation; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : The fundamental building blocks of chromatin are the nucleosomes. Each such unit is composed of about 200 bp of DNA, the well-conserved core histones (H2A, H2B, H3 and H4) and a linker histone (H1). LÄS MER

  7. 40. The Control of the Epigenome

    Författare :Magda Lezcano; Rolf Ohlsson; Matthias Merkenschlager; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Epigenetics; chromosome interactions; replication timing; histone modifications; epigenetic surveillance; Biologi; Biology; Biologi;

    Sammanfattning : The genetic information required for the existence of a living cell of any kind is encoded in the sequence information scripted in the double helix DNA. A modern trend in biology struggles to come to grip with the amazing fact that there are so many different cell types in our body and that they are directed from the same genomic blueprint. LÄS MER