Sökning: "epigenetic surveillance"

Hittade 4 avhandlingar innehållade orden epigenetic surveillance.

  1. 1. The Control of the Epigenome

    Författare :Magda Lezcano; Rolf Ohlsson; Matthias Merkenschlager; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Epigenetics; chromosome interactions; replication timing; histone modifications; epigenetic surveillance; Biologi; Biology; Biologi;

    Sammanfattning : The genetic information required for the existence of a living cell of any kind is encoded in the sequence information scripted in the double helix DNA. A modern trend in biology struggles to come to grip with the amazing fact that there are so many different cell types in our body and that they are directed from the same genomic blueprint. LÄS MER

  3. 2. Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome

    Författare :Patrick Joost; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mismatch repair; Lynch syndrome; immunohistochemistry; microsatellite instability; heterogeneity; cumulative incidence; colorectal cancer; urothelial cancer; prostate cancer; renal cell cancer;

    Sammanfattning : Mismatch repair (MMR) deficiency is carcinogenic and can either have somatic/sporadic causes (i.e. epigenetic silencing or somatic inactivation) or hereditary causes (Lynch syndrome due to a germline mutation in one of the MMR genes ¬- MLH1, MSH2, MSH6, PMS2). LÄS MER

  4. 3. Elucidation of the molecular mechanisms of action of anti-cancer compounds reveals possible combination strategies for anti-cancer therapy

    Författare :Xiaolei Zhou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer develops due to accumulation of mutations or epigenetic changes within normal cells, usually over a considerable period of time. When cancer patients are diagnosed at late stage, the tumor cells are often more heterogenous and aggressive, which results in tumor resistance to anti-cancer therapies and therefore can be lethal. LÄS MER

  5. 4. Promoter mutations/methylation in thyroid and urothelial carcinomas : biological and clinical implications

    Författare :Xiangling Xing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genetic and epigenetic aberrations are well established to drive cancer development and progression. However, the underlying mechanisms are incompletely understood, and the translational applications of aberrant alterations are limited in gene non-coding regions, such as the promoter locus. LÄS MER