Sökning: "histone H4 methylation"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden histone H4 methylation.
1. Chromatin, histones, and epigenetic tags
Sammanfattning : The fundamental building blocks of chromatin are the nucleosomes. Each such unit is composed of about 200 bp of DNA, the well-conserved core histones (H2A, H2B, H3 and H4) and a linker histone (H1). LÄS MER
2. Genome-wide patterns of histone modifications in fission yeast
Sammanfattning : DNA is wrapped almost two times around a group of proteins called histones to form a chromosomal structure known as the nucleosome. Both DNA and histones can be modified with different chemical tags by several enzymes to activate or suppress a particular gene or group of genes. Histones can be covalently modified at several places. LÄS MER
3. The oncogenic role of histone chaperone ASF1 proteins in solid tumors
Sammanfattning : Chromatin is the essential medium connecting regulatory signals such as transcription factors and signaling pathways to the alteration of gene activity and cellular phenotypes. Aberrant chromatin (epigenetic) environment plays an important role in carcinogenesis. LÄS MER
4. On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate
Sammanfattning : Development of an organism requires correct spatial and temporal regulation of gene expression. Epigenetic regulation of gene expression has been shown to be an important part of many cellular events. Nucleosomes consist of two subunits of each core histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. LÄS MER
5. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells
Sammanfattning : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. LÄS MER