Sökning: "DEGs"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet DEGs.

  1. 1. Regulation of insulin secretion in diabetes: Molecular mechanism and applications

    Författare :Rui Wu; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin production secretion; CaV channels; DEGs; aging; magnetic field;

    Sammanfattning : Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. In this thesis, we aim to explore the underlying roles of CaV channels and aging-associated genetic changes in the development of Type 2 diabetes (T2D). LÄS MER

  3. 2. Response to waterlogging and drought of timothy and related Phleum species: phenotype and transcriptome diversity

    Författare :Silvana Moreno; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Timothy (Phleum pratense) is a cool-season perennial forage grass commonly used in temperate regions for silage, hay and grazing. Climate change is causing abiotic stresses on agriculture and there is an increasing need for tolerant cultivars. LÄS MER

  4. 3. Digital Twins : High Resolution Disease Models for Optimized Diagnosis and Treatment

    Författare :Sandra Lilja; Mikael Benson; Huan Zhang; Claudio Altafini; Yvan Saeys; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : To study immune-mediated diseases, which can affect the expression of thousands of genes among many different cell types and organs, is a daunting challenge. However, for effective diagnosis and therapeutic treatment it is relevant to understand the regulatory functions of disease. LÄS MER

  5. 4. Functional genomics of diapause in two temperate butterflies

    Författare :Peter Pruisscher; Karl Gotthard; Dieter Ebert; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; diapause induction; adaptation; genomics; transcriptomics; populationsgenetik; Population Genetics;

    Sammanfattning : Natural selection will act on a given phenotype to maximize fitness in a particular environment, even if this would result in reduced fitness in other environments. In insects some of the strongest selection pressures act on timing life cycles to seasonal variation in environmental conditions, in order to maximize growth, reproduction, and to anticipate the onset of winter. LÄS MER

  7. 5. A transcriptomic tale of two worms : Evaluating Caenorhabditis elegans as a model for Parascaris univalens in drug resistance studies

    Författare :Faruk Dube; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Parascaris univalens, an equine roundworm, poses a significant threat to foals, potentially causing lethal intestinal ruptures in high infestations. Infection control relies on a limited arsenal of anthelmintic drugs like ivermectin (IVM). LÄS MER