Sökning: "islet inflammation"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden islet inflammation.

  1. 1. Formation of Composite Islet Grafts : A novel strategy to promote islet survival and revascularization

    Författare :Ulrika Johansson; Peetra Magnusson; Korsgren Olle; Bo Nilsson; Federico Bertuzzi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet of Langerhans; cytokines and cytokinereceptors expression; endothelial cells; mesenchymal stromal cells; transplantation; revascularization; Clinical immunology; Klinisk immunologi; cellforskning; cellforskning;

    Sammanfattning : The islets of Langerhans are small and delicate spheroid organs scattered in the pancreas responsible for insulin production. Transplantation of isolated islets is a beneficial therapy for patients with a severe form of type 1 diabetes. LÄS MER

  3. 2. The Best Leading Role for Maintaining Normal β-cell Function Goes to MafA and Voltage-gated Calcium Channel Subunit γ4

    Författare :Cheng Luan; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; insulin secretion; pancreatic islet; MafA; CaVγ4; CaV channels; β-cell function; dedifferentiation; transcription factor; patch clamp; Ca2 signaling; cholinergic nicotinic receptor; ChrnB4; GDF11; aging; islet inflammation; maturation;

    Sammanfattning : .... LÄS MER

  4. 3. The Role of Innate Immunity in Islet Transplantation : Clinical and Experimental Studies

    Författare :Lisa Moberg; Bo Nilsson; Olle Korsgren; Kristina Nilsson Ekdahl; Rolf Larsson; David Harlan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; diabetes; islet transplantation; islet of Langerhans; coagulation activation; IBMIR; tissue factor; thrombin; inactivated FVIIa; melagatran; neutrophilic granulocyte; Immunologi; Immunology; Immunologi;

    Sammanfattning : Clinical islet transplantation is an emerging procedure to cure type 1 diabetes. The graft is implanted by infusion into the liver through the portal vein. A major obstacle that still needs to be overcome is the requirement for islets from multiple donors to achieve insulin independence. LÄS MER

  5. 4. Transcriptional and morphological analysis of organ donor pancreata

    Författare :Anton Stenwall; Oskar Skog; Lena Eliasson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreas; Diabetes; Islet of Langerhans; Beta-cell; Immunology; Inflammation; Ageing; Biology with specialization in Molecular Immunology; Biologi med inriktning mot molekylär immunologi;

    Sammanfattning : The diabetes disease panorama affects more than 400 million people world wide – a number projected to rise above 640 million in the next 20 years. Type 1 and type 2 diabetes are associated with adverse complications, resulting in severe morbidity and high healthcare costs exerting substantial strain on society. LÄS MER

  7. 5. Diabetes in Young Adults : Remission, β-cell function and markers of inflammation

    Författare :Anna Schölin; Elisabeth Björk; Anders Karlsson; Jan Åman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Internal medicine; type 1 diabetes; young adults; remission; β-cell function; islet antibodies; gender; CRP; Invärtesmedicin; Internal medicine; Invärtesmedicin; Internal Medicine; invärtesmedicin;

    Sammanfattning : Type 1 diabetes is caused by immuno-mediated β-cell destruction leading to insulin deficiency and hyperglycaemia. The decline in β-cell function and the clinical course after diagnosis vary. Whether the process of destruction of the β-cells is associated with markers of a non-specific inflammatory response is unknown. LÄS MER