Sökning: "DNA radicals"

Visar resultat 16 - 20 av 40 avhandlingar innehållade orden DNA radicals.

  1. 16. Oxidant-induced cell death in lymphocytes: mechanisms of induction and resistance

    Författare :Fredrik Bergh Thorén; Göteborgs universitet; []
    Nyckelord :reactive oxygen species; cell death; apoptosis; poly ADP-ribose polymerase-1; apoptosis-inducing factor; natural killer cells; phagocytes; dendritic cells;

    Sammanfattning : Reactive oxygen species (oxidants, oxygen radicals) produced by the phagocytic NADPH oxidase have pivotal roles in immunity. Patients lacking a functional NADPH oxidase suffer from chronic granulomatous disease, which is characterized by recurring bacterial infections and thus manifesting the importance of reactive oxygen species in host defense against bacteria. LÄS MER

  3. 17. Identification of Arthritis Regulating Genes in Rats

    Författare :Peter Olofsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; transplantation; Clinical genetics; Klinisk genetik; serology; Immunology; QTL; RA; Epistasis; Ncf1; Linkage; PIA; Arthritis; Rat;

    Sammanfattning : The immune response is designed to protect the body from harmful microbial invasions. However, when the immune system attacks itself instead, an autoimmune reaction starts that damage our own cells, tissues and organs. LÄS MER

  4. 18. An X-ray Based Spectroscopic Study of Structure Influencing Electrons : Fragmentation, Ultrafast Charge Dynamics and Surface Composition

    Författare :Geethanjali Gopakumar; Olle Björneholm; Carl Caleman; Isaak Unger; Ruth Signorell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fragmentation; ICD; ETMD; Ultrafast electron dynamics; Surface propensity;

    Sammanfattning : The structure of biomolecules, such as proteins, is intimately connected to the function of the molecules. These structures are often studied using X-ray diffraction. However, the interaction of the X-ray photons with the molecule can excite or ionize its electrons which in turn can causes changes in the molecular structure. LÄS MER

  5. 19. Alloxan Toxicity to macrophages and Insulinoma Cells

    Författare :Hong Zhang; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Alloxan induces damage and death of pancreatic islet B-cells in severalexperimental animal models, thus causing insulin-dependent diabetes mellitus (IDDM or type I diabetes). This unique cytotoxicity of alloxan has been studied for more than fifty years. LÄS MER

  7. 20. Oligomerization of human and bacterial frataxin : Structural and functional studies

    Författare :Mostafa Abdalkhalik; Biokemi och Strukturbiologi; []
    Nyckelord :Frataxin; Friedreich’s ataxia; iron; reactive oxiden species; protein oligomerization; SAXS; EM; cross-linking; XAFS; nano- DSF;

    Sammanfattning : Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. LÄS MER