Sökning: "nano- DSF"

Hittade 2 avhandlingar innehållade orden nano- DSF.

1. 1. Oligomerization of human and bacterial frataxin : Structural and functional studies

   Författare :Mostafa Abdalkhalik; Biokemi och Strukturbiologi; []
   Nyckelord :Frataxin; Friedreich’s ataxia; iron; reactive oxiden species; protein oligomerization; SAXS; EM; cross-linking; XAFS; nano- DSF;

   Sammanfattning : Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. LÄS MER

3. 2. Targeting glutathione peroxidases : identifying environmental modulators, and screening for novel small molecule inhibitors

   Författare :Dorian M. Cheff; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Glutathione peroxidases (GPXs) are a family of selenoproteins that are critical regulators of reactive oxygen species (ROS) in the cell, specifically hydroperoxides like hydrogen peroxide (H2O2). ROS are important for normal cell signaling and are tightly controlled to promote cell growth, proliferation, and survival. LÄS MER