Sökning: "D2"

Visar resultat 1 - 5 av 198 avhandlingar innehållade ordet D2.

1. 1. Population Pharmacodynamic Modeling and Methods for D2-receptor Antagonists

   Författare :Klas Petersson; Lena Friberg; Mats Karlsson; An Vermeulen; Robert Bies; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; population modeling; schizophrenia; D2-antagonists; pharmacodynamics; drug development;

   Sammanfattning : Early predictions of a potential drug candidate’s time-course of effect and side-effects, based on models describing drug concentrations, drug effects and disease progression, would be valuable to make drug development more efficient. Pharmacodynamic modeling can incorporate and propagate prior knowledge and be used for simulations of different scenarios. LÄS MER

3. 2. Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo

   Författare :Fredrik Pettersson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dopamine; D2; monoamine oxidase; DOPAC; in vivo; QSAR; dopaminergic stabilizer;

   Sammanfattning : The endogenous neurotransmitter dopamine (DA) is involved in several functions that are controlled from the central nervous system (CNS), for example behaviour, memory, cognition and reward. A disturbed dopaminergic neurotransmission may lead to many severe conditions, such as schizophrenia, attention deficit hyperactivity disorder (ADHD) or Parkinson's disease (PD). LÄS MER

4. 3. Reactivity of Metal Clusters with Diatomic Molecules

   Författare :Lotta Holmgren; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nbn; cluster; reactivity; Rhn; NO; D2; CO; N2; laser vaporization; Wn; Nin; photoionization; time-of-flight mass spectrometer; ionization potential; Cun; O2; Vn;

   Sammanfattning : The reactivity of transition-metal clusters, in the approximate size range 10-60 atoms, with diatomic molecules has been investigated. A pulsed beam of neutral clusters is produced by a laser-vaporization source and passed through a low-pressure reaction cell containing the reactive gas. LÄS MER

5. 4. Metal Cluster Reactivity. Adsorption of small molecules in biomolecular collisions

   Författare :Mats Andersson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; O2; CO; ionization potential; Con; Fen; NO; sticking probability; laser ionization; D2; Wn; Cun; Rhn; reaction probability; cluster; jellium model; Nbn; metal cluster reactivity; N2; time-of-flight mass spectrometry; Nin;

   Sammanfattning : Metal clusters can be characterized as the tiniest possible metal particles, containing only an easily counted number of atoms. In this work, reactions between metal clusters and diatomic molecules have been investigated. We have constructed an experimental set-up to produce and detect clusters, and to investigate their chemical reactivity. LÄS MER

7. 5. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies

   Författare :Maria Wanderoy; Eliassitet Eriksson; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

   Sammanfattning : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. LÄS MER