Sökning: "Crystalline compounds"

Visar resultat 11 - 15 av 68 avhandlingar innehållade orden Crystalline compounds.

  1. 11. Novel and refined small-scale approaches to determine the intrinsic dissolution rate of drugs

    Författare :Sara B. E. Andersson; Göran Alderborn; Göran Frenning; Peter Langguth; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dissolution; intrinsic dissolution rate; poorly water-soluble compounds; single particle dissolution; solubility; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Many drugs are administered as crystalline particles compressed into tablets and taken orally. When the tablet reaches the gastrointestinal tract, it disintegrates and the drug particles dissolve in the gastrointestinal fluid. The dissolved molecules are absorbed across the intestinal membranes into the bloodstream to reach their target sites. LÄS MER

  3. 12. Pressure-Induced Amorphization and Distinct Amorphous States of Clathrate Hydrates

    Författare :Paulo H. B. Brant Carvalho; Ulrich Häussermann; Ove Andersson; John Stephen Loveday; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Clathrate Hydrates; Pressure-Induced Amorphization; Amorphous States; Glassy States; Ice; Neutron Diffraction; Klatrathydrater; Tryckinducerad Amorfisering; Amorfa tillstånd; Glasartade tillstånd; Is; Neutrondiffraktion; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : This thesis summarizes a study on the pressure-induced amorphization (PIA) and structures of amorphous states of clathrate hydrates (CHs).PIA involves the transition of a crystalline material into an amorphous solid in response of mechanical compression at temperatures well below the melting point. LÄS MER

  4. 13. Computational and Experimental Models for the Prediction of Intestinal Drug Solubility and Absorption

    Författare :Christel A. S. Bergström; Per Artursson; Han van de Waterbeemd; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; aqueous drug solubility; melting point; intestinal drug permeability; pH-dependent solubility; multivariate data analysis; molecular descriptors; molecular surface area; in silico modeling; drug absorption; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vast increase in the number of pharmacologically interesting compounds. However, the number of new drugs undergoing clinical trial has not augmented at the same pace, which in part has been attributed to poor absorption of the compounds. LÄS MER

  5. 14. Hg Cuprate Superconductors Technological and Conceptual Tools

    Författare :Rafael Gatt; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mercury; high pressure; pulsed laser deposition; crystal growth; high temperature superconductors; cluster calculations; flat bands; thin oxide films; powder diffraction; structure refinement; phase transition; electronic structure; liquid phase epitaxy;

    Sammanfattning : This work concerns superconductivity in the cuprates. It touches some of the problems that this field displays. As a representing case, the Hg based cuprates are chosen. LÄS MER

  7. 15. Chemical exposures, biological monitoring and cancer risks in Swedish aluminium foundries and remelting plants

    Författare :Håkan Westberg; Hans Welinder; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : In aluminium foundries and remelting plants, a wide range of chemical agents are formed and emitted, including some highly toxic organochlorine compounds. This thesis explores emissions and exposures, as well as worker risk of porphyria and cancer. LÄS MER