Sökning: "CART"
Visar resultat 1 - 5 av 38 avhandlingar innehållade ordet CART.
1. The role of CART in islet function
Sammanfattning : Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. LÄS MER
2. Ghrelin and CART. Two new islet peptides. Expression, regulation and function
Sammanfattning : Until recently, the islets of Langerhans were thought to harbour four main cell types characterised with respect to principal hormone product. Here we show that the novel hormone ghrelin is expressed in a fifth islet cell type, the islet ghrelin cell, in humans and rodents. LÄS MER
3. Influence of Islet-derived Factors in Islet Microcirculation and Endocrine Function
Sammanfattning : Diabetes mellitus is a disorder with complex pathology and is frequently associated with vascular complications. In the islet micro milieu locally generated factors may affect both the physiology and the morphology of the tissue. LÄS MER
4. Physiological Studies of Native and Stem Cell-Derived Islets
Sammanfattning : In type 1 and type 2 diabetes, the β-cells of the islets of Langerhans are either destroyed by the immune system or stressed due to peripheral insulin resistance. To improve the life of patients with these diseases, new treatments are needed. LÄS MER
5. Hirschsprung´s Disease & Gastroesophageal Reflux. Aspects on Two Gastrointestinal Motility Disorders in Childhood
Sammanfattning : Gastrointestinal motility disorders are common in childhood and in this thesis we look at two of them, i.e. Hirschsprung´s Disease (HD) and gastroesophageal reflux disease (GERD) in five different studies. LÄS MER