Sökning: "islets"

Visar resultat 1 - 5 av 303 avhandlingar innehållade ordet islets.

  1. 1. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

    Författare :Joey Lau; Per-Ola Carlsson; Leif Jansson; Carina Carlsson; Caroline Kampf; Annika Tibell; Uppsala universitet; []
    Nyckelord :Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

    Sammanfattning : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. LÄS MER

  2. 2. Leukocytes in Angiogenesis : Learning from Transplanted Pancreatic Islets

    Författare :Gustaf Christoffersson; Mia Phillipson; Kristian Pietras; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; pancreatic islet transplantation; islets of Langerhans; diabetes mellitus; leukocytes; neutrophils; macrophages; pericytes; MMP-9; VEGF-A; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Angiogenesis, the growth of new blood vessels, is a complex process involving several cell types and molecular signals. Excessive vascular growth is a problem in tumors, and insufficient vascularization hampers the function of transplanted insulin-producing pancreatic islets. LÄS MER

  3. 3. CFTR in pancreatic islets

    Författare :Anna Edlund; Diabetes - öcellsexocytos; []
    Nyckelord :CFTR; CF; CFRD; Cystic fibrosis; Cystisk fibros; Diabetes; Insulin; Beta cell; Glukagon; Glucagon; Alpha cell; Alfa-cell; Anoctamin; ANO1; ANO;

    Sammanfattning : AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. LÄS MER

  4. 4. Microcirculation in native and transplanted rodent pancreatic islets with special reference to the influence of diabetes mellitus

    Författare :Per-Ola Carlsson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; islet microcirculation; microspheres; micropuncture technique; islet blood flow; islet capillary pressure; oxygen tension; transplanted islets; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : The aim of the present work was to characterize the islet microcirculation in animal models of type 1 and type 2 diabetes, as well as in islets transplanted to diabetic or normoglycemic recipients. For this purpose, a microsphere technique was evaluated and applied for measurements of islet blood flow in mice. LÄS MER

  5. 5. Microencapsulation of Pancreatic Islets : A Non-Vascularised Transplantation Model

    Författare :Sara Bohman; Arne Andersson; Aileen King; Stellan Sandler; Eduard Montanya; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Microencapsulation; Islet transplantation; revascularisation; alpha-cell; exendin-4; islet amyloid; Cell biology; Cellbiologi;

    Sammanfattning : Transplantation of pancreatic islets is a potential treatment of type 1 diabetes that aims to restore normal blood glucose control. By encapsulating the islets in alginate, they can be protected from rejection. LÄS MER