Sökning: "Brain Repair and Imaging in Neural Systems BRAINS"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden Brain Repair and Imaging in Neural Systems BRAINS.

1. 6. Novel strategies for enzyme replacement with gene therapy in models of Parkinson’s disease

   Författare :Erik Cederfjäll; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AAV vectors; dopamine; enzyme replacement; gene regulation; GTP cyclohydrolase 1; L-DOPA; tyrosine hydroxylase; Parkinson’s disease;

   Sammanfattning : Parkinson’s disease is a brain disorder characterized by loss of dopaminergic neurons in the midbrain, resulting in the characteristic motor symptoms: resting tremor, rigidity, akinesia and postural instability. Symptomatic treatment is based on reconstituting the loss of dopamine in the brain, primarily by oral administration of its precursor L-DOPA. LÄS MER

3. 7. Pre- and postsynaptic dysregulation of dopamine signalling in Parkinson's disease

   Författare :Gurdal Sahin; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :[18F]fallypride; 3-OMD; AAV; blood-brain barrier; dyskinesia; HVA; L-DOPA; microdialysis; modeling; Parkinson’s disease; pharmacokinetics; positron-emission tomography; prediction; RNA interference; shRNA;

   Sammanfattning : .... LÄS MER

4. 8. Development of lentiviral vectors for CNS gene transfer

   Författare :Johan Jakobsson; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Biotechnology; Gene Therapy; Neurological disorders;

   Sammanfattning : Gene therapy in the brain is a promising treatment strategy that in the future may be used for several brain disorders, including Parkinson's disease, Alzheimer's disease and lysosomal storage diseases. By introducing a new gene, rather than providing a classical pharmacological drug, gene therapy offers the opportunity to treat neurological disorders by a single intervention. LÄS MER

5. 9. Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application

   Författare :Tomas Björklund; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serotonin; Parkinson’s disease; L-DOPA; dyskinesia; GTP cyclohydrolase 1; tyrosine hydroxylase; dopamine; gene therapy; enzyme replacement; gene regulation; aromatic L-amino acid decarboxylase;

   Sammanfattning : The introduction of L-DOPA pharmacotherapy revolutionized the treatment of Parkinson’s disease close to fifty years ago. Before the discovery of dopamine as a neurotransmitter and its involvement in the disease, these patients had very little aid from medication and were bound to a life without movement. LÄS MER

7. 10. Pathogenic effects of alpha-synuclein: modifications and toxicity

   Författare :Natalie Landeck; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :Parkinson s disease; adeno-associated viral vector; animal models; alpha-synuclein; substantia nigra; dopaminergic neurons; phosphorylation; aggregation; toxicity;

   Sammanfattning : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. LÄS MER