Sökning: "Biomedical Radiation Science"

Visar resultat 16 - 20 av 32 avhandlingar innehållade orden Biomedical Radiation Science.

1. 16. EGFR- and HER2-Binding Affibody Molecules : Cellular studies of monomeric, dimeric and bispecific ligands

   Författare :Lina Ekerljung; Lars Gedda; Johan Lennartsson; Jörgen Carlsson; Birgitta Sundström; Uppsala universitet; []
   Nyckelord :EGFR; HER2; Affibody molecule; cell signaling; receptor dimerization; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Sammanfattning : Abnormal expression and signaling of the ErbB receptors is associated with the development and progression of several forms of cancer. In this thesis, new ErbB-targeting affibody molecules are evaluated regarding their cellular effects in vitro. LÄS MER

3. 17. Two-Step Targeting for Effective Radionuclide Therapy : Preclinical Evaluation of 125I-labelled Anthracycline Delivered by Tumour Targeting Liposomes

   Författare :Amelie Fondell; Lars Gedda; Detlef Gabel; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radionuclide; Auger electrons; liposomes; targeting; tumour therapy; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Sammanfattning : For the treatment of cancer, Auger-electron emitting radionuclides are strongly dependent on their close proximity to DNA to utilize the local therapeutic potential of the Auger electrons. This thesis investigates a two-step targeting approach that uses targeting liposomes for the delivery of an Auger-electron emitter, 125I, coupled to a DNA-binding compound, Comp1, to the tumour-cell DNA. LÄS MER

4. 18. Expressions of mercury-selenium interaction in vitro

   Författare :Peter Frisk; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; growth inhibition; inorganic mercury; interaction; organic mercury; selenite; selenomethionine; toxicity; uptake; Onkologi; Oncology; Onkologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

   Sammanfattning : Interaction between mercury and selenium has previously been observed both in man and in animals. The aim of this work was to study expressions of interaction between mercury and selenium in human K-562 cells. LÄS MER

5. 19. Biomechanical assessment of head and neck movements in neck pain using 3D movement analysis

   Författare :Helena Grip; Gertjan Ettema; Umeå universitet; []
   Nyckelord :movement analysis; kinematics; helical axis; neck pain; whiplash; cervical spine; pattern classification; motor control; head-eye co-ordination; head movement; biomedicinsk strålningsvetenskap; Biomedical Radiation Science;

   Sammanfattning : Three-dimensional movement analysis was used to evaluate head and neck movement in patients with neck pain and matched controls. The aims were to further develop biomechanical models of head and neck kinematics, to investigate differences between subjects with non-specific neck pain and whiplash associated disorders (WAD), and to evaluate the potential of objective movement analysis as a decision support during diagnosis and follow-up of patients with neck pain. LÄS MER

7. 20. Spatio-temporal processing of surface electromyographic signals : information on neuromuscular function and control

   Författare :Christer Grönlund; Leif Sörnmo; Umeå universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; EMG; multichannel surface electromyography; motor unit action potentials; conduction velocity; muscle architecture; signal quality; spatial distributions; synchronization; muscle function; motor control; biomedicinsk strålningsvetenskap; Biomedical Radiation Science;

   Sammanfattning : During muscle contraction, electrical signals are generated by the muscle cells. The analysis of those signals is called electromyography (EMG). The EMG signal is mainly determined by physiological factors including so called central factors (central nervous system origin) and peripheral factors (muscle tissue origin). LÄS MER