Sökning: "Biomedical Radiation Science"
Visar resultat 11 - 15 av 32 avhandlingar innehållade orden Biomedical Radiation Science.
11. Searching for Synergy : Radiosensitization of 177Lu-DOTATATE
Sammanfattning : Cancers presents a major health challenge, and there is a pressing need to develop new therapeutic strategies. Surgery, chemotherapy and radiation are the most commonly used treatments for cancer today. Radiation can be given as targeted radionuclide therapy (TRT), i.e. LÄS MER
12. Tumour targeting with stable and radioactive nuclides : Dosimetric aspects at the cellular level
Sammanfattning : Targeting with radioactive nuclides or nuclides that can be activated by neutrons may be a powerful tool for treatment of invasive tumours and disseminated tumour cells. The targeting agents are designed to find tumour cells and deliver the nuclides. LÄS MER
13. Indirect Radiohalogenation of Targeting Proteins : Labelling Chemistry and Biological Characterisation
Sammanfattning : In about half of all newly diagnosed cancer cases, conventional treatment is not adequately curative, mainly due to the failure of conventional techniques to find and kill residual cells and metastases, which might consist of only a few malignant cells, without causing unacceptable complications to healthy tissue. To solve the problem a more selective delivery of cytotoxic substances to tumour cells is needed. LÄS MER
14. Tumor Cell Targeting of Stabilized Liposome Conjugates : Experimental studies using boronated DNA-binding agents
Sammanfattning : To further develop cancer therapy, targeted delivery of cell killing agents directly to tumor cells is an interesting approach. This thesis describes the development of PEG-stabilized liposome conjugates targeting either epidermal growth factor receptor (EGFR) using its natural ligand EGF, or human epidermal growth factor receptor 2 (HER-2) using the antibody trastuzumab. LÄS MER
15. Harnessing the molecular Trojan horse : Evaluating properties of preclinical Aβ immunoPET radioligands for optimized brain delivery via the transferrin receptor
Sammanfattning : With high specificity and selectivity to targets, antibodies are prime candidates for positron emission tomography (PET) radioligands. They do not passively cross the blood-brain barrier which has hindered their development for imaging intrabrain targets, like amyloid-β (Aβ) in Alzheimer’s disease. LÄS MER