Sökning: "Biomedical Radiation Science"

Visar resultat 21 - 25 av 32 avhandlingar innehållade orden Biomedical Radiation Science.

  1. 21. Development of Affibody molecules for radionuclide molecular imaging and therapy of cancer

    Författare :Hadis Honarvar; Vladimir Tolmachev; Raymond M. Reilly; Uppsala universitet; []
    Nyckelord :Affibody molecules; HER2; Molecular imaging; Radionuclide targeted therapy; Radionuclide molecular imaging; Labeling chemistry; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Affibody molecules are a promising class of scaffold-based targeting proteins for radionuclide-based imaging and therapy of cancer. This thesis work is based on 5 original research articles (papers I-V), which focus on optimization of molecular design of HER2-binding Affibody variants for high contrast imaging of this predictive biomarker as well as development of Affibody molecules suitable for radionuclide-based targeted therapies. LÄS MER

  3. 22. Precision medicine and targeted therapy : Turning the tables on cancer

    Författare :Anja Mortensen; Marika Nestor; Gregory Adams; Uppsala universitet; []
    Nyckelord :p53 cancers; PM2; radiosensitization; radio-immunotherapy; MDM2 X inhibition; combination therapy; targeted radionuclide therapy; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : An extended understanding of the molecular characteristics of cancer has led to a revolution within the field of precision medicine. This thesis explores the utilization of two targets for precision medicine, namely, CD44v6 and murine double-minute 2 and X (MDM2/X). LÄS MER

  4. 23. Radionuclide targeting with particular empahsis on urinary bladder carcinoma

    Författare :Anna Sjöström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Sammanfattning : The incidence of urinary bladder carcinoma is increasing and many patients die every year of this disease despite assumed radical therapy. Thus, there is a need for improved methods of diagnosis and therapy. LÄS MER

  5. 24. Affibody Molecules for PET Imaging

    Författare :Joanna Strand; Tolmachev Vladimir; Sten Nilsson; Uppsala universitet; []
    Nyckelord :Affibody molecules; Molecular imaging; PET; Radiolabelling; HER2; PDGFRβ; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. LÄS MER

  7. 25. Radiotherapy for head and neck cancer : costs and benefits of time, dose and volume

    Författare :Karin Söderström; Björn Zackrisson; Werner Dubrowsky; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiotherapy; head and neck cancer; adjuvant treatment; accelerated fractionation; biomedicinsk strålningsvetenskap; Biomedical Radiation Science;

    Sammanfattning : Background In the treatment of head and neck cancers (HNCs), radiotherapy (RT) has the advantage of organ preservation compared to surgery. However, treatment toxicities associated with RT can affect important functions for everyday life, both in the acute and late stage. LÄS MER