Sökning: "receptor dimerization"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden receptor dimerization.

  1. 1. New Paradigms in GPCR Drug Discovery Structure Prediction and Design of Ligands with Tailored Properties

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mariama Jaiteh; Jens Carlsson; David E Gloriam; [2020]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Docking; Virtual Screening; Homology Modeling; Molecular Dynamics Simulation; Chemical Library; Functionally Selective Ligand; Polypharmacology; Dimerization; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER

  2. 2. Structure and function of the HDL receptor SR-BI : scavenger receptor class B type I

    Detta är en avhandling från Göteborg

    Författare :Magnus S.C. Johnson; Göteborgs universitet.; Gothenburg University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SR-BI; HDL; Cholesterol; Scavenger receptor; Apoptosis; Ovary; Gallbladder; Peroxisome;

    Sammanfattning : Low plasma levels of high-density lipoprotein (HDL) and high levels of low-density lipoprotein (LDL) are well-recognized risk factors for cardiovascular disease. The uptake and degradation of LDL cholesterol have been characterized in detail at the molecular level. Less is known about the metabolism and cellular uptake of HDL cholesterol. LÄS MER

  3. 3. Receptors for growth hormone and prolactin. Regulation and activation

    Detta är en avhandling från Göteborg

    Författare :Gunnel Hellgren; Göteborgs universitet.; Gothenburg University.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; GH receptor; Janus kinase; GH sensitivity; 5 -untranslated region; prolactin; prolactin receptor adipose tissue; liver; skeletal muscle; epidermal growth factor receptor; tyrosine kinase; kinase activity;

    Sammanfattning : Cytokine receptor activation is dependent on ligand-induced receptor dimerization or oligomerization and subsequent activation of several intracellular proteins. Activation of Janus kinases (Jaks) is probably the first intracellular event that occurs after receptor dimerization. LÄS MER

  4. 4. EGFR- and HER2-Binding Affibody Molecules Cellular studies of monomeric, dimeric and bispecific ligands

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Lina Ekerljung; Uppsala universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EGFR; HER2; Affibody molecule; cell signaling; receptor dimerization; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Abnormal expression and signaling of the ErbB receptors is associated with the development and progression of several forms of cancer. In this thesis, new ErbB-targeting affibody molecules are evaluated regarding their cellular effects in vitro. LÄS MER

  5. 5. Specific signaling through heteromeric PDGF receptor complexes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Simon Ekman; Uppsala universitet.; [2000]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal cells and exert its effect by binding to two structurally related receptor tyrosine kinases, denoted α- and β-receptors. PDGF binding induces dimerization of its receptors, both homo-and heterodimerization, leading to their autophosphorylation on tyrosine residues and binding of downstream signaling molecules. LÄS MER