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Visar resultat 21 - 25 av 96 avhandlingar som matchar ovanstående sökkriterier.

1. 21. Cryo-EM and Computational Biology of Macromolecular Complexes

   Författare :Andrew Emmerich; Suparna Sanyal; Erik Lindahl; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The ribosome is a large, ancient multicomponent macromolecular complex which is highly amenable to study by cryogenic electron microscopy (cryo-EM) and computation biology methods. This thesis delves into the structure of both prokaryotic and eukaryotic ribosomes in the context of determining a solution to emerging antimicrobial resistance. LÄS MER

3. 22. Single-cell RNA sequencing provides novel insights into spider development and represents an innovative alternative to study the evolution and development of panarthropods

   Författare :Brenda Irene Medina-Jiménez; Ralf Janssen; Graham Budd; Angelika Stollewerk; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; panarthropod; spider embryo; single-cell RNA sequencing; EvoDevo; candidate gene approach; gene expression; cluster marker; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Earth Science with specialization in Historical Geology and Palaeontology; Geovetenskap med inriktning mot historisk geologi och paleontologi;

   Sammanfattning : Panarthropoda is a monophyletic group of invertebrate animals with a segmented body, paired appendages, dorsal brain, and ventral nerve cords. In order to study the mechanisms underpining their evolution, I study the genetic factors that drive their development. LÄS MER

4. 23. PARN - A Tale of A de-Tailor : Functional importance of poly(A) degradation in developmental and telomere biology disorders

   Författare :Sethu Madhava Rao Gunja; Anders Virtanen; Jonas von Hofsten; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PARN; Telomere biology disorders; snoRNAs; scaRNAs; TR TERC; Zebrafish; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Molekylär genetik; Molecular Genetics; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Poly(A)-specific ribonuclease (PARN) is a eukaryotic 3’-5’exoribonuclease that removes poly(A) tails of many coding and non-coding RNAs. In this thesis, we have studied the physiological role of PARN. LÄS MER

5. 24. Mechanisms of plant root xylem developmental plasticity in response to water deficiency and salt

   Författare :Frauke Augstein; Annelie Carlsbecker; Eva Sundberg; Charles Melnyk; Malcolm Bennett; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ABA; developmental plasticity; GA; HD-ZIP III; VND; xylem; Biologi med inriktning mot fysiologisk botanik; Biology with specialization in Physiological Botany;

   Sammanfattning : Plants may be exposed to a variety of different environmental conditions including water deficiency and salt, both affecting the uptake of water into the plant. Water is taken up from the soil by the roots and distributed throughout the plant via the water conducting tissue, the xylem. LÄS MER

7. 25. Solid-phase Proximity Ligation Assays : High-performance and multiplex protein analyses

   Författare :Spyros Darmanis; Masood Kamali-Moghaddam; Ulf Landegren; Mathias Uhlen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; proximity ligation assay; multiplexed; biomarkers; solid-phase; microparticles; cancer; sequencing; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Sammanfattning : Protein biomarkers circulating in blood hold the promise of improved diagnosis, prognosis and follow-up of treatment of disease via minimally invasive procedures. For the discovery and validation of such biomarkers, methods are needed that can facilitate parallel, highly specific and in-depth analysis of the blood proteome. LÄS MER