Sökning: "Autoantigens"

Visar resultat 11 - 15 av 51 avhandlingar innehållade ordet Autoantigens.

  1. 11. RNA-protein complexes as autoantigens : cell and molecular biology of Ro/SSA and disease associations of anti-Ro/SSA antibodies

    Författare :Nader Pourmand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ro SSA; Ro 52kD; Ro 60kD; p40phox; Ig classes; systemic lupus erythematosus; Sjögren s syndrome; autoantibodies; immunoblotting;

    Sammanfattning : Autoantibodies to the Ro/SSA and La/SSB antigens are present in sera from patients with Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). The Ro/SSA autoantigen consists of a 52kD and a 60kD protein, complexed with one of four small RNAs. The La protein can also associate with the complex. LÄS MER

  3. 12. Aspects of autoantibody epitopes in type 1 diabetes

    Författare :Hanna Skärstrand; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Minor autoantigens Neuropeptide Y.; Affinity; ZnT8 autoantibodies; Autoimmune type 1 diabetes;

    Sammanfattning : Type 1 diabetes (T1D) is strongly associated with autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to classify diabetes at the time of clinical onset. LÄS MER

  4. 13. Inhibition of T cell responses to autoantigens and allergens by CD25+ regulatory T cells from thymus, cord and adult blood

    Författare :Kajsa Wing; Göteborgs universitet; []
    Nyckelord :Tolerance; CD25 regulatory T cells; adult peripheral blood; cord blood; thymus; autoimmune disease; allergy;

    Sammanfattning : Autoimmune diseases and allergies are a growing problem in the western world today. Tolerance is primarily established by clonal deletion in the thymus. Despite this auto-reactive T cells are normally present in most individuals, which suggests that mechanisms of peripheral tolerance operate to silence potentially pathogenic T cells. LÄS MER

  5. 14. Autoantigenic properties of the U1-70K protein

    Författare :Elisabet Welin Henriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :U1-70K protein; ribonucleoproteins; autoantigens; autoantibodies; epitopemapping; connective tissue disease; species specificity; cross reactions; amino acidsequence; recombinant proteins; mutagenesis;

    Sammanfattning : Patients with the autoimmune diseases systemic lupus erythematosus and mixed connective tissue disease produce autoantibodies directed towards specific groups of cellular constituents in their own body. Two of the targeted antigens are denoted Sm and RNP, and consist of distinct collections of splicing associated RNA-protein complexes. LÄS MER

  7. 15. Pituitary autoantibodies in endocrine disorders

    Författare :Sophie Bensing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lymphocytic hypophysitis; hypopituitarism; empty sella syndrome; APS 1; autoantibodies; autoantigen; Secretogranin II; TDRD6.;

    Sammanfattning : Autoimmune endocrine disorders are characterised by the development of autoantibodies to specific autoantigens in the target organs. Lymphocytic hypophysitis (LyH) is a disease characterised by inflammation of the pituitary gland, often resulting in hypopituitarism. The aetiology of LyH is considered to be autoimmune. LÄS MER