Sökning: "Ig classes"

Hittade 4 avhandlingar innehållade orden Ig classes.

  1. 1. RNA-protein complexes as autoantigens : cell and molecular biology of Ro/SSA and disease associations of anti-Ro/SSA antibodies

    Författare :Nader Pourmand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ro SSA; Ro 52kD; Ro 60kD; p40phox; Ig classes; systemic lupus erythematosus; Sjögren s syndrome; autoantibodies; immunoblotting;

    Sammanfattning : Autoantibodies to the Ro/SSA and La/SSB antigens are present in sera from patients with Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). The Ro/SSA autoantigen consists of a 52kD and a 60kD protein, complexed with one of four small RNAs. The La protein can also associate with the complex. LÄS MER

  3. 2. The rise and fall of IgE

    Författare :Molly Vernersson; Rikard Holmdahl; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Immunoglobulin; IgE; evolution; atopic allergy; vaccine; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Immunology; molekylär immunologi;

    Sammanfattning : Immunoglobulin E (IgE) occurs exclusively in mammals and is one of five immunoglobulin (Ig) classes found in man. Unlike other isotypes, IgE is best known for its pathological effects, whereas its physiological role remains somewhat elusive. LÄS MER

  4. 3. Studies on the immuno-modulating properties of the cholera toxin A1-based fusion protein CTA1-DD

    Författare :Anna Eriksson; Göteborgs universitet; []
    Nyckelord :adjuvant; cholera toxin; mucosa; targeting; B cell; immuno-modulation; vaccine;

    Sammanfattning : The present work was aimed at exploring the immuno-modulating properties of the novel cholera toxin (CT)-based vaccine adjuvant CTA1-DD, which combines the full enzymatic activity of the A1 subunit of CT with B cell targeting. We have studied the efficacy of the CTA1-DD adjuvant to enhance immune responses in mice after nasal administration. LÄS MER

  5. 4. Histopathological and immunocytochemical studies in age-associated dementias : the importance of rigorous histopathological criteria for classification of progressive dementia disorders

    Författare :Irina Alafuzoff; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Dementia is an age-associated organic brain disorder, recogniz­able by the essential features of psychological or behavioral abnormality associated with permanent dysfunction of the brain interfering with social and occupational functioning.There are two clinical and three histopathological forms of dementia 1) primary degenerative dementia, (PDD), or Alzhei­mer's dementia/Senile dementia of Alzheimers type (AD/SDAT) which is associated with clinical features of uniform progres­sion and insidious onset of symptoms and histopathologically i- dentified by the occurrence of neurofibrillary tangles (NFT) and senile/neuritic plaques (SP/NP) in various cortical and subcor- tical regions; 2) vascular dementia, or multi-infarct dementia (MID), which is associated with clinical features of stepwise progress and patchy distribution of deficits, and histopatholo­gically identified by the occurrence of multiple large and/or small haemorrhagic and/or ischaemic infarcts in various cortical and subcortical regions and 3) intermediate form of dementia or "mixed” ("combined") dementia (AD-MID), which is histopatho- logically associated with the coexistance of symptoms and le­sions observed in AD/SDAT and MID, and clinically referred to the MID group. LÄS MER