Sökning: "Amyloid Detection"
Visar resultat 6 - 10 av 59 avhandlingar innehållade orden Amyloid Detection.
6. Amyloid Fibril Formation - Dye Detection and Effects of Lipids
Sammanfattning : Amyloid fibrils are long fibrillar homopolymers of self-assembled proteins. They can be formed by essentially any polypeptide, but are of particular interest because of their occurrence in several incurable and debilitating human diseases, e.g. Alzheimer’s disease (AD). LÄS MER
7. Electrophoretic focusing in microchannels combined with mass spectrometry : Applications on amyloid beta peptides
Sammanfattning : Analysis of low-abundance components in small samples remains a challenge within bioanalytical chemistry, and new techniques for sample pretreatments followed by sensitive and informative detection are required. In this thesis, procedures for preconcentration and separation of proteins and peptides in open microchannels fabricated on silicon microchips are presented. LÄS MER
8. Development of the Amyloid Fibril Characterisation Toolbox - New use for old dyes
Sammanfattning : Amyloid fibrils are self-assembled protein homopolymers that playcentral roles in the pathology of several human diseases, most notably in progressiveneurodegenerative diseases such as Alzheimer’s disease (AD). In AD, fibrils areformed by the amyloid-β (Aβ) peptide, an enzymatic cleavage product that is naturallyproduced in human brain tissue. LÄS MER
9. Detection of Lipids and Proteins on Biological Surfaces using Imaging Mass Spectrometry
Sammanfattning : Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique that can be used for imaging the spatial distribution of many different molecules at the same time. It is very sensitive for detection of small biomolecules, such as lipids, whereas larger biomolecules, such as peptides and proteins, cannot be detected as intact entities due to fragmentation. LÄS MER
10. Asymmetric Oligothiophenes : Chemical Evolution of Multimodal Amyloid Ligands
Sammanfattning : Luminescent conjugated polymers (LCPs) and luminescent conjugated oligothiophenes (LCOs) can be used as molecular probes to study diseases associated with protein aggregation. The conventionally used dyes to study and detect protein aggregates, denoted amyloid, have been Congo red (CR) and Thioflavin T (ThT). LÄS MER
