Sökning: "Alendronate"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet Alendronate.

1. 1. Aspects of fracture prevention - The role of fracture liaison services and alendronate

   Författare :Kristian F Axelsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoporosis; Prevention; Fracture; Fracture liaison service; Alendronate; Elderly; Prednisolone;

   Sammanfattning : Objective: In an ageing population, osteoporotic fractures become more common and cause increased morbidity, mortality and societal cost. This thesis aimed to determine the potential role of fracture liaison services (FLS) and alendronate treatment on fracture risk in those with a recent fracture, in the elderly and in those treated with oral prednisolone. LÄS MER

3. 2. Titanium Oxide and Bone Anchorage: Role of the Complement System, and Delivery of Osteoporosis Drugs from Mesoporous TiO2

   Författare :Necati Harmankaya; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; titania; complement; photocatalysis; ovariectomy; alendronate; raloxifene;

   Sammanfattning : The clinical success of bone implants of titanium (Ti) is largely ascribed to the biological performance and the physicochemical properties of the outermost titanium(IV)dioxide (TiO2) layer. Several advancements have been done on TiO2 in order to optimize its healing and anchorage to bone, and there is a need for further understanding and control of the molecular reactions preceding long-term osseointegration. LÄS MER

4. 3. Pharmacological Modulation of Skeletal Homeostasis

   Författare :Niklas U. Andersson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Farmakologi; toxicology; farmakognosi; farmaci; toxikologi; pharmacy; pharmacognosy; Pharmacological sciences; peripheral quantitative computed tomography.; dual energy X-ray absorptiomenty; estrogen; parathyroid hormone; gastrectomy; alendronate; ovariectomy; Bone;

   Sammanfattning : Both ovariectomy (OVX) and gastrectomy (GX) cause osteopenia in several animal species including humans. While the effect of OVX has been ascribed to estrogen deficiency, the underlying mechanism behind GX-induced osteopenia is poorly understood. LÄS MER

5. 4. Benefits and harms of Bisphosphonates : an observational study

   Författare :Jonathan Bergman; Peter Nordström; Miia Kivipelto; Håkan Melhus; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; osteoporosis; fracture; alendronate; risedronate; zoledronic acid; glucocorticoid; mortality; osteonecrosis; register; registry; real-world evidence; epidemiology; Geriatrics; geriatrik; epidemiologi; Epidemiology;

   Sammanfattning : Background: Bisphosphonates are first-line treatment for osteoporosis, but osteoporosis is considered an undertreated disease. The general aim of this dissertation was to further study the benefits and harms of bisphosphonates. LÄS MER

7. 5. Mesoporous Implants for Localized Controlled Drug Delivery

   Författare :Johan Karlsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; release kinetics; mesoporous titania; biomineralization; drug delivery; Biomedical implants; osseointegration; osteoporosis drugs; nanotopography; stem cells homing;

   Sammanfattning : The use of bone-anchored implants is today a routine treatment for patients with normal regenerative capacity. However, there is an ongoing development within implant research to improve the osseointegration of implants. LÄS MER